Topographic modifications of the substrate of a cell culture have the potential to guide cell
polarization and migration, through which epidermal wound healing may be accelerated …

During cancer progression the extracellular matrix is remodeled, forming aligned collagen
fibers that proceed radially from the tumor, resulting in invasion. We have recently shown …

Biophysical cues encoded in the extracellular matrix (ECM) are increasingly being explored
to control cell behavior in tissue engineering applications. Recently, we showed that cell …

In order to study how cells change their traction forces at focal adhesions (FAs) following cell
contraction, we observed the dynamic changes in traction forces at FAs, the morphology of …

Recent experiments have shown that spreading epithelial sheets exhibit a long-range
coordination of motility forces that leads to a buildup of tension in the tissue, which may …

Material surfaces can induce cell responses such as contact guidance, yet little attention has
been paid to further cell orientation. Herein, we report an interesting phenomenon of cell …

Tracks of adhesiveness are believed to be involved in guiding morphogenetic cell
migrations. Here, electronics microfabrication technology was used to manufacture patterns …

Epithelial cells assemble specialized actomyosin structures at E-Cadherin–based cell–cell
junctions, and the force exerted drives cell shape change during morphogenesis. The …

In wound healing and development, large epithelial sheets migrate collectively, in defined
directions, and maintain tight cell–cell adhesion. This type of movement ensures an …

Contact guidance is a powerful topographical cue that induces persistent directional cell
migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix …