Water insolubility has always been a key obstacle in pharmaceutical formulation, affecting
formulation stability and drug bioavailability. Approaches for achieving complete dissolution …

An increasing percentage of drug development candidates suffer from poor aqueous
solubility which in turn often times leads to poor oral absorption. This poses significant …

An increasing number of newly developed drugs are poorly soluble; in many cases drugs
are poorly soluble in both aqueous and organic media excluding the traditional approaches …

Introduction: For poorly soluble compounds, a good bioavailability is typically needed to
assess the therapeutic index and the suitability of the compound for technical development …

In vitro drug release kinetics studies are routinely performed to examine the ability of new
drug formulations to modulate drug release. The underlying assumption is that the studies …

Solid dispersions are one of the most promising strategies to improve the oral bioavailability
of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and …

Poor water solubility is an industry wide issue, especially for pharmaceutical scientists in
drug discovery and drug development. In recent years, nanoparticle engineering processes …

This short paper is a personal account of the development of techniques to enhance the
bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer …

An ideal drug delivery system should be able to deliver an adequate amount of drug,
preferably for an extended period of time for its optimum therapeutic activity. Most drugs are …

Oral delivery of drugs with poor aqueous solubility and poor enzymatic and/or metabolic
stability is very challenging. However, the advent of nanotechnology has revolutionized the …