Causes of clonal hematopoiesis: a review

LJ Joo, CC Bradley, SH Lin, PA Scheet… - Current oncology reports, 2023 - Springer
Abstract Purpose of Review Clonal hematopoiesis (CH) is an age-dependent process
detectable using advanced sequencing technologies and is associated with multiple …

[PDF][PDF] Regulators of clonal hematopoiesis and physiological consequences of this condition

E Park, MA Evans, K Walsh - J Cardiovasc Aging, 2024 - f.oaes.cc
Clonal hematopoiesis (CH) is a prevalent condition that results from somatic mutations in
hematopoietic stem cells. When these mutations occur in “driver” genes, they can potentially …

Clinical and Therapeutic Implications of Clonal Hematopoiesis

G Petrone, I Turker, P Natarajan… - Annual Review of …, 2024 - annualreviews.org
Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …

The clinical management of clonal hematopoiesis: creation of a clonal hematopoiesis clinic

KL Bolton, A Zehir, RN Ptashkin… - Hematology …, 2020 - hemonc.theclinics.com
Hematol Oncol Clin N Am 34 (2020) 357–367 https://doi. org/10.1016/j. hoc. 2019.11. 006
hemonc. theclinics. com 0889-8588/20/© 2019 Elsevier Inc. All rights reserved. phenotype …

Clonal hematopoiesis: a shared risk factor for cardiovascular diseases and tumors

LF Zha, X Cheng - Oncology and Translational Medicine, 2024 - journals.lww.com
Clonal hematopoiesis (CH) is a clonally expanded population of hematopoietic stem cells
carrying somatic mutations that differentiate through multilineage hematopoiesis to form …

Germline Predisposition for Clonal Hematopoiesis

Y Kubota, AD Viny - Seminars in Hematology, 2024 - Elsevier
Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent
overrepresentation of cells from a common stem/progenitor lineage harboring single …

[HTML][HTML] Decoding Clonal Hematopoiesis: Emerging Themes and Novel Mechanistic Insights

S Pendse, D Loeffler - Cancers, 2024 - mdpi.com
Simple Summary The expansion of mutant cells that outgrow and displace normal blood
cells is called clonal hematopoiesis (CH). CH starts with the acquisition of mutations in blood …

Germline risk of clonal haematopoiesis

AJ Silver, AG Bick, MR Savona - Nature Reviews Genetics, 2021 - nature.com
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Clonal hematopoiesis in survivors of childhood cancer

D Novetsky Friedman, ICC Chan… - Blood …, 2023 - ashpublications.org
Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem
and progenitor cells, is associated with the development of hematologic cancers …

Novel associations between clonal hematopoiesis and therapeutic exposures revealed in patients with solid tumors using real world evidence

A Sonnenschein, E Moore, C Lo, P Kang, TJ Taxter… - Blood, 2022 - ashpublications.org
Clonal hematopoiesis (CH) occurs when somatic mutations confer a fitness advantage in
blood cells enabling them to outcompete, increases with age, and has been linked to greater …