Designing nanozymes that match natural enzymes have always been an attractive and
challenging goal. In general, researchers mainly focus on the construction of metal centers …

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in
tumors holds great promise for the reversal of the immunosuppressive tumor …

The aggressive proliferation of tumor cells often requires increased glucose uptake and
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …

Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …

An effective systemic mechanism regulates tumor development and progression; thus, a
rational design in a one‐stone‐two‐birds strategy is meant for cancer treatment. Herein, a …

As a class of functional proteins, enzymes possess inherent insignificant features, for
instance, mediocre stability and membrane impermeability and reduced enzymatic activity …

Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as
artificial enzymes in biomedicine. However, how to control their in vivo performance in a …

Nanocatalytic tumor therapy is an emerging antitumor option that employs catalytically‐
active inorganic nanostructures to produce tumor‐damaging reactive oxygen species …

Nanocatalytic therapy, involving the nanozyme‐triggered production of reactive oxygen
species (ROS) in the tumor microenvironment (TME), has demonstrated potential in tumor …

Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …