Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …

Background Ageing displays clear sexual dimorphism, evident in both morbidity and
mortality. Ageing is also associated with changes in DNA methylation, but very little focus …

Recently, it has been proposed that age‐related X chromosome inactivation (XCI) skewing
can clinically result in late‐onset X‐linked disorders. This observation leads to hypothesize …

Background Large numbers of autosomal sites are found differentially methylated in the
aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome …

The Y chromosome, a sex chromosome that only exists in males, has been ignored in
traditional epigenetic association studies for multiple reasons. However, sex differences in …

Background: Ageing is a heterogenous process characterised by cellular and molecular
hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for …

X-chromosome inactivation (XCI) achieves dosage compensation between males and
females through the silencing of the majority of genes on one of the female X chromosomes …

In this study we applied a new analytical strategy to investigate the relations between
stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through …

X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the
majority of genes on one X chromosome in each female cell. To characterize epigenetic …

In view of the sex differences in aging‐related diseases, sex chromosomes may play a
critical role during aging process. This study aimed to identify age‐related DNA methylation …