The effects of ovariectomy and estrogen replacement on myocardial contractility were
examined in female rabbits. Ovariectomy failed to alter left ventricular mass, papillary muscle …

Previous studies have shown that 17 beta-estradiol (beta-E2) has a direct acute inhibitory
effect on vascular smooth muscle (VSM) contraction. To investigate the mechanisms …

We have investigated the role of endothelium-derived relaxing factors, K+ channels and
steroid receptors in vasorelaxation to testosterone in the rat aorta. Testosterone (1 nM–mM) …

17 beta‐Oestradiol (E2) at 0.1‐10 microM directly inhibited various tonic and phasic smooth
muscle contractions. The mechanism (s) of oestrogen‐induced inhibition of contraction was …

The progestin and oestrogen component of oral contraceptives have been involved in the
development of venous thromboembolic events in women. In the present study we …

Estrogens initiate their action by binding to specific intracellular receptors and then acting on
gene expression. In addition, there is growing evidence of a direct membrane effect via …

2-Methoxyestradiol, an endogenous metabolite of 17β-estradiol, is known to have antitumor
and antiangiogenic actions. The effects of 2-methoxyestradiol on ionic currents were …

Oestrogen can modify the contractile function of vascular smooth muscle and
cardiomyocytes. The negative inotropic actions of oestrogen on the heart and coronary …

Acute estrogen administration relaxes vascular smooth muscle by decreasing intracellular
Ca2+ concentration ([Ca2+] i). In the present study, we examined the hypothesis that this …

The potency and maximum effect of the calcium entry blocker nifedipine as an inhibitor of
uterine contractions in vivo are increased in rats in late pregnant compared with non …