[HTML][HTML] Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety

F Fan, L Yang, R Li, X Zou, N Li, X Meng… - Biomedicine & …, 2020 - Elsevier
Salidroside (Sal) is a bioactive extract principally from traditional herbal medicine such as
Rhodiola rosea L., which has been commonly used for hundreds of years in Asia countries …

Neuroprotective effects of salidroside on cerebral ischemia/reperfusion-induced behavioral impairment involves the dopaminergic system

Z Zhong, J Han, JZ Zhang, Q Xiao, J Chen… - Frontiers in …, 2019 - frontiersin.org
Salidroside, a phenylpropanoid glycoside, is the main bioactive component of Rhodiola
rosea L. Salidroside has prominent anti-stroke effects in cerebral ischemia/reperfusion …

Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases

J Han, L Luo, Y Wang, S Wu, V Kasim - Frontiers in Pharmacology, 2022 - frontiersin.org
Rhodiola is an ancient wild plant that grows in rock areas in high-altitude mountains with a
widespread habitat in Asia, Europe, and America. From empirical belief to research studies …

[HTML][HTML] Pharmacological effects of salidroside on central nervous system diseases

M Jin, C Wang, Y Xu, Z Zhang, X Wu, R Ye… - Biomedicine & …, 2022 - Elsevier
Salidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high
altitudes. It has been proven to have protective effects on myocardial injury, liver cancer …

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Z Zhong, J Han, J Zhang, Q Xiao, J Hu… - Drug design …, 2018 - Taylor & Francis
The primary objective of this review article was to summarize comprehensive information
related to the neuropharmacological activity, mechanisms of action, toxicity, and safety of …

Synergistic effects of salvianolic acid B and puerarin on cerebral ischemia reperfusion injury

C Ling, J Liang, C Zhang, R Li, Q Mou, J Qin, X Li… - Molecules, 2018 - mdpi.com
Ischemic stroke (IS) is characterized by the sudden loss of blood circulation to an area of the
brain, resulting in a corresponding loss of neurologic function. It has been a worldwide …

Protective potential of hydroxysafflor yellow A in cerebral ischemia and reperfusion injury: An overview of evidence from experimental studies

L Yu, Z Jin, M Li, H Liu, J Tao, C Xu, L Wang… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke, mostly caused by thromboembolic or thrombotic arterial occlusions, is a
primary leading cause of death worldwide with high morbidity and disability. Unfortunately …

Suppressing receptor-interacting protein 140: a new sight for salidroside to treat cerebral ischemia

T Chen, Z Ma, L Zhu, W Jiang, T Wei, R Zhou… - Molecular …, 2016 - Springer
The purpose of the current study was to detect the effect of salidroside (Sal) on cerebral
ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was …

Salidroside reduces inflammation and brain injury after permanent middle cerebral artery occlusion in rats by regulating PI3K/PKB/Nrf2/NFκB signaling rather than …

X Zhang, W Lai, X Ying, L Xu, K Chu, J Brown, L Chen… - Inflammation, 2019 - Springer
Salidroside, an active constituent of Rhodiola rosea, is neuroprotective after transient middle
cerebral artery occlusion (tMCAO). However, its effects in other experimental stroke models …

Neuroprotective effects of salidroside on focal cerebral ischemia/reperfusion injury involve the nuclear erythroid 2-related factor 2 pathway

J Han, Q Xiao, Y Lin, Z Zheng, Z He… - Neural Regeneration …, 2015 - journals.lww.com
Salidroside, the main active ingredient extracted from Rhodiola crenulata, has been shown
to be neuroprotective in ischemic cerebral injury, but the underlying mechanism for this …