Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

The topography of a biomaterial regulates cellular interactions and determine stem cell fate.
A complete understanding of how topographical properties affect cell behavior will allow the …

Topography-driven alterations in cell morphology tremendously influence cell biological
processes, particularly stem cell differentiation. Aligned topography is known to alter the cell …

A wide variety of environmental factors including physical and biochemical signals are
responsible for stem cell behavior and function. In particular, matrix elasticity and cell shape …

There is a dynamic relationship between physical and biochemical signals presented in the
stem cell microenvironment to guide cell fate determination. Model systems that modulate …

Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …

Learning rules by which cell shape impacts cell function would enable control of cell
physiology and fate in medical applications, particularly, on the interface of cells and …

Regenerative medicine affords an effective approach for restoring defect-associated
diseases, and biomaterials play a pivotal role as cell niches to support the cell behavior and …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

Signals from the microenvironment around a cell are known to influence cell behavior.
Material properties, such as biochemical composition and substrate stiffness, are today …