[HTML][HTML] Optogenetics for visual restoration: from proof of principle to translational challenges
Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …
Optogenetic approaches to vision restoration
Inherited retinal disease (IRD) affects about 1 in 3000 to 1 in 5000 individuals and is now
believed to be the most common cause of blindness registration in developed countries …
believed to be the most common cause of blindness registration in developed countries …
Optogenetic gene therapy for the degenerate retina: recent advances
ME McClements, F Staurenghi, RE MacLaren… - Frontiers in …, 2020 - frontiersin.org
The degeneration of light-detecting rod and cone photoreceptors in the human retina leads
to severe visual impairment and ultimately legal blindness in millions of people worldwide …
to severe visual impairment and ultimately legal blindness in millions of people worldwide …
Optogenetic therapy for visual restoration
D Sakai, H Tomita, A Maeda - International Journal of Molecular Sciences, 2022 - mdpi.com
Optogenetics is a recent breakthrough in neuroscience, and one of the most promising
applications is the treatment of retinal degenerative diseases. Multiple clinical trials are …
applications is the treatment of retinal degenerative diseases. Multiple clinical trials are …
Optogenetic approaches to therapy for inherited retinal degenerations
SR De Silva, AT Moore - The Journal of physiology, 2022 - Wiley Online Library
Inherited retinal degenerations such as retinitis pigmentosa (RP) affect around one in 4000
people and are the leading cause of blindness in working age adults in several countries. In …
people and are the leading cause of blindness in working age adults in several countries. In …
Advances in ophthalmic optogenetics: approaches and applications
Recent advances in optogenetics hold promise for vision restoration in degenerative eye
diseases. Optogenetics refers to techniques that use light to control the cellular activity of …
diseases. Optogenetics refers to techniques that use light to control the cellular activity of …
Current approaches to vision restoration using optogenetic therapy
K Parnami, A Bhattacharyya - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Inherited progressive degeneration of photoreceptors such as retinitis pigmentosa (RP) is
the most common cause of blindness leading to severe vision impairment affecting~ 1 in …
the most common cause of blindness leading to severe vision impairment affecting~ 1 in …
Bioengineering strategies for restoring vision
Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …
[HTML][HTML] Optogenetics for retinal disorders
BS Henriksen, RE Marc… - Journal of ophthalmic & …, 2014 - ncbi.nlm.nih.gov
Optogenetics is the use of genetic methods combined with optical technology to achieve
gain or loss of function within neuronal circuits. The field of optogenetics has been rapidly …
gain or loss of function within neuronal circuits. The field of optogenetics has been rapidly …