Abstract Design and manipulation of scaffolds are essential to improve cellular functions for
regeneration of functional bone constructs in tissue engineering and regenerative medicine …

The ability to control the interactions of stem cells with synthetic surfaces is proving to be
effective and essential for the quality of passaged stem cells and ultimately the success of …

The patterning of biological components into structural analogues of native tissues to
simulate an environment for directing cell growth is one important strategy in biomaterials …

Inspired by ultrastructural analysis of ex vivo human tissues as well as the physiological
importance of structural density, we fabricated nanogrooves with 1: 1, 1: 3 and 1: 5 spacing …

In the 2000s, advances in cellular micropatterning using microfabrication contributed to the
development of cell-based biosensors for the functional evaluation of newly synthesized …

Intricate structures of natural surfaces and materials have amazed people over the ages.
The unique properties of various surfaces also created interest and curiosity in researchers …

Controlling the spatial organization of cells is vital in engineering tissues that require
precisely defined cellular architectures. For example, functional nerves or blood vessels …

Micro-and nanoengineering of materials offer novel technologies and serve as an interface
between material sciences and biomedical nanotechnology. Various techniques are used …

Cellular organization, migration and proliferation in three-dimensions play a critical role in
numerous physiological and pathological processes. Nano-and micro-fabrication …

Many studies have demonstrated the potential to modulate stem cell differentiation by using
static material substrate surfaces. However, cells actually grow in a dynamically diverse …