BACKGROUND: Studies in humans and mice using the expression of an X-linked gene or
lineage tracing, respectively, have suggested that clones of smooth muscle cells (SMCs) …

Gomez and Owens SMC Clonal Expansion in Atherosclerosis 1263 wild-type cells might
undergo selective clonal expansion or selection and end up being the dominant cell type …

During atherosclerosis, local secretion of chemokines and growth factors following
endothelial injury, adhesion of platelets, and infiltration of inflammatory cells into the intima …

Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. While
many cell types contribute to the growing atherosclerotic plaque, the vascular smooth …

The monoclonal theory of atherosclerosis postulates that the initial vascular smooth muscle
cell (VSMC) proliferative event involves the expansion of a single cell or a sub-population of …

During atheromatous plaque formation or restenosis after angioplasty, smooth muscle cells
(SMCs) migrate from the media toward the intima, where they proliferate and undergo …

Recently, there has been a dramatic change in the way we think about the role of vascular
smooth muscle cells in atherosclerosis, and it is now generally accepted that a dearth of …

Objectives. The purpose of this study was to determine whether the kinetics of smooth
muscle cell outgrowth from in vitro explants of human atherosclerotic tissue is dependent on …

The monoclonal theory of atherosclerosis postulates that a certain subpopulation of vascular
smooth muscle cells (VSMC) is selectively expanded in response to pathological stimuli …

The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that
aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced …