Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans

S Bagnato, C Boccagni - Neural regeneration research, 2020 - journals.lww.com
Traumatic brain injury (TBI) is the paradigmatic example of acute brain injury, defined as
sudden and unexpected structural and/or functional damage to the brain. In western …

Traumatic brain injury as a trigger of neurodegeneration

VE Johnson, W Stewart, JD Arena, DH Smith - … Mechanisms, and Potential …, 2017 - Springer
Although millions of individuals suffer a traumatic brain injury (TBI) worldwide each year, it is
only recently that TBI has been recognized as a major public health problem. Beyond the …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Prognostic-factors for neurodegeneration in chronic moderate-to-severe traumatic brain injury: a systematic review protocol

B Sharma, A Changoor, L Monteiro, B Colella… - Systematic reviews, 2020 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and disability. Recently,
a paradigm shift in our understanding of moderate-to-severe TBI has led to its …

Brain injury as a neurodegenerative disorder

REA Green - Frontiers in human neuroscience, 2016 - frontiersin.org
The acute stage of moderate-severe traumatic brain injury (TBI) entails the rapid unfolding of
pathophysiological processes secondary to biomechanical damage that eventually stabilize …

Progressive histopathological damage occurring up to one year after experimental traumatic brain injury is associated with cognitive decline and depression-like …

X Mao, NA Terpolilli, A Wehn, S Cheng… - Journal of …, 2020 - liebertpub.com
Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) is
associated with progressive histopathological damage. The aim of the current study was to …

Post-traumatic neurodegeneration and chronic traumatic encephalopathy

DH Daneshvar, LE Goldstein, PT Kiernan… - Molecular and Cellular …, 2015 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world.
Concussive and subconcussive forms of closed-head injury due to impact or blast …

Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies

CH Huang, CW Lin, YC Lee, CY Huang, RY Huang… - BMC neurology, 2018 - Springer
Background To determine the association of prior traumatic brain injury (TBI) with
subsequent diagnosis of neurodegeneration disease. Methods All studies from 1980 to …

The impact of traumatic brain injury on later life: effects on normal aging and neurodegenerative diseases

GS Griesbach, BE Masel, RE Helvie… - Journal of …, 2018 - liebertpub.com
The acute and chronic effects of traumatic brain injury (TBI) have been widely described;
however, there is limited knowledge on how a TBI sustained during early adulthood or mid …

Multimodal characterization of the late effects of traumatic brain injury: a methodological overview of the late effects of traumatic brain injury project

BL Edlow, CD Keene, DP Perl, D Iacono… - Journal of …, 2018 - liebertpub.com
Epidemiological studies suggest that a single moderate-to-severe traumatic brain injury
(TBI) is associated with an increased risk of neurodegenerative disease, including …