Thermodynamic insights into the structural basis governing the donor substrate recognition by human β1, 4-galactosyltransferase 7
F Daligault, S Rahuel-Clermont, S Gulberti… - Biochemical …, 2009 - portlandpress.com
Human β1, 4-GalT (galactosyltransferase) 7 is involved in the biosynthesis of the
tetrasaccharide linker protein region (GlcAβ1→ 3Galβ1→ 3Galβ1→ 4Xylβ1)(where GlcA is …
tetrasaccharide linker protein region (GlcAβ1→ 3Galβ1→ 3Galβ1→ 4Xylβ1)(where GlcA is …
[HTML][HTML] Identification of key functional residues in the active site of human β1, 4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway
I Talhaoui, C Bui, R Oriol, G Mulliert, S Gulberti… - Journal of biological …, 2010 - ASBMB
Glycosaminoglycans (GAGs) play a central role in many pathophysiological events, and
exogenous xyloside substrates of β1, 4-galactosyltransferase 7 (β4GalT7), a major enzyme …
exogenous xyloside substrates of β1, 4-galactosyltransferase 7 (β4GalT7), a major enzyme …
[HTML][HTML] Crystal structures of β-1, 4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding
Y Tsutsui, B Ramakrishnan, PK Qasba - Journal of Biological Chemistry, 2013 - ASBMB
The β-1, 4-galactosyltransferase 7 (β4GalT7) enzyme is involved in proteoglycan synthesis.
In the presence of a manganese ion, it transfers galactose from UDP-galactose to xylose on …
In the presence of a manganese ion, it transfers galactose from UDP-galactose to xylose on …
[HTML][HTML] Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human β1, 4-galactosyltransferase 7 (GalT-I) and β1, 3 …
S Gulberti, V Lattard, M Fondeur, JC Jacquinet… - Journal of Biological …, 2005 - ASBMB
We determined whether the two major structural modifications, ie phosphorylation and
sulfation of the glycosaminoglycan-protein linkage region (GlcAβ1–3Galβ1–3Galβ1 …
sulfation of the glycosaminoglycan-protein linkage region (GlcAβ1–3Galβ1–3Galβ1 …
Investigations on β1, 4-galactosyltransferase I using 6-sulfo-GlcNAc as an acceptor sugar substrate
B Ramakrishnan, AJ Moncrief, TA Davis… - Glycoconjugate …, 2013 - Springer
sulfate modified N-acetylglucosamine (6-sulfo-GlcNAc) is often found as part of many
biologically important carbohydrate epitopes such as 6-sulfo-Le X. In these epitopes, the 6 …
biologically important carbohydrate epitopes such as 6-sulfo-Le X. In these epitopes, the 6 …
[HTML][HTML] Probing the acceptor active site organization of the human recombinant β1, 4-galactosyltransferase 7 and design of xyloside-based inhibitors
M Saliba, N Ramalanjaona, S Gulberti… - Journal of Biological …, 2015 - ASBMB
Among glycosaminoglycan (GAG) biosynthetic enzymes, the human β1, 4-
galactosyltransferase 7 (hβ4GalT7) is characterized by its unique capacity to take over …
galactosyltransferase 7 (hβ4GalT7) is characterized by its unique capacity to take over …
[HTML][HTML] Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the β1, 3-galactosyltransferase …
X Bai, D Zhou, JR Brown, BE Crawford… - Journal of Biological …, 2001 - ASBMB
A family of five β1, 3-galactosyltransferases has been characterized that catalyze the
formation of Galβ1, 3GlcNAcβ and Galβ1, 3GalNAcβ linkages present in glycoproteins and …
formation of Galβ1, 3GlcNAcβ and Galβ1, 3GalNAcβ linkages present in glycoproteins and …
[HTML][HTML] The dimeric structure of wild-type human glycosyltransferase B4GalT1
D Harrus, F Khoder-Agha, M Peltoniemi, A Hassinen… - PLoS …, 2018 - journals.plos.org
Most glycosyltransferases, including B4GalT1 (EC 2.4. 1.38), are known to assemble into
enzyme homomers and functionally relevant heteromers in vivo. However, it remains …
enzyme homomers and functionally relevant heteromers in vivo. However, it remains …
[HTML][HTML] N-glycosylation of the human β1, 4-galactosyltransferase 4 is crucial for its activity and Golgi localization
A Shauchuk, B Szulc, D Maszczak-Seneczko… - Glycoconjugate …, 2020 - Springer
Abstract β1, 4-galactosyltransferase 4 (B4GalT4) is one of seven B4GalTs that belong to
CAZy glycosyltransferase family 7 and transfer galactose to growing sugar moieties of …
CAZy glycosyltransferase family 7 and transfer galactose to growing sugar moieties of …
Improving solubility of catalytic domain of human β‐1, 4‐galactosyltransferase 1 through rationally designed amino acid replacements
M Malissard, EG Berger - European journal of biochemistry, 2001 - Wiley Online Library
β‐1, 4‐galactosyltransferase 1 (β4gal‐T1, EC 2.4. 1.38) transfers galactose from UDP‐
galactose to free N‐acetyl‐d‐glucosamine or bound N‐acetyl‐d‐glucosamine‐R. Soluble …
galactose to free N‐acetyl‐d‐glucosamine or bound N‐acetyl‐d‐glucosamine‐R. Soluble …