The human corneal basement membrane has a rich felt-like surface topography with feature
dimensions between 20 nm and 200 nm. On the basis of these findings, we designed …

We have previously shown that human corneal epithelial cells sense and react to nanoscale
substrate topographic stimuli [Teixeira AI, Abrams GA, Bertics PJ, Murphy CJ, Nealey PF …

The basement membrane possesses a rich 3-dimensional nanoscale topography that
provides a physical stimulus, which may modulate cell-substratum adhesion. We have …

We have previously shown that human corneal epithelial cells respond to synthetic
topographic features with dimensions similar to those found in the native human corneal …

The purpose of this study was to evaluate the effect of surface topographic features that
mimic the corneal epithelial basement membrane on cell migration. We used electron‐beam …

The cornea is a complex tissue composed of different cell types, including corneal epithelial
cells and keratocytes. Each of these cell types are directly exposed to rich nanoscale …

Topographic features are generally accepted as being capable of modulating cell alignment.
Of particular interest is the potential that topographic feature geometry induces cell …

Cell adhesion, orientation and migration are influenced by surface topographies in the
micrometer and nanometer range. In this work, we demonstrate the stimulation by …

Purpose.: Keratocyte-to-myofibroblast differentiation is a key factor in corneal wound
healing. The purpose of this study was to determine the influence of environmental …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …