X-inactivation is a random process that occurs in females early during embryogenesis.
Females are mosaics with an equal proportion of cells with the paternal (Xp) or maternal X …

Stably acquired mutations in hematopoietic cells represent substrates of selection that may
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …

Post-zygotic variation refers to genetic changes that arise in the soma of an individual and
that are not usually inherited by the next generation. Although there is a paucity of research …

Context.—The clinical association between loss of the Y chromosome and acute
myelogenous leukemia and myelodysplastic syndrome (AML/MDS) has been debated …

Replicative stress during embryonic development influences ageing and predisposition to
disease in adults. A protective mechanism against replicative stress is provided by the …

The partial tandem duplication of MLL (MLL-PTD) is found in 5% to 10% of patients with
acute myeloid leukemia (AML) and normal cytogenetics. Its expression in leukemic blasts is …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …