Objectives/Hypothesis Determine the optimal design characteristics of an adenoviral (Ad)
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …

Loss of auditory and vestibular hair cells is a common cause of hearing loss and balance
disorders. A variety of strategies have been proposed to restore function to damaged inner …

Conclusion: Replacement of vestibular hair cells induced by atoh1 driven by the tissue-
specific GFAP promoter was significantly more efficient than use of the cBA or hCMV …

Therapies for the protection and regeneration of auditory hair cells are of great interest given
the significant monetary and lifestyle impact of hearing loss. The past decade has seen …

Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …

Balance dysfunction is closely associated with loss of vestibular hair cells (HCs). Gene
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …

Vestibular hair cells (HCs) are mechanoreceptors for the detection of head movement.
Vestibular HCs of adult mammals never completely regenerate after damage, resulting in …

Background Loss of vestibular hair cell is seen in various balance disorder diseases. There
have been some reports concerning gene delivery to the mouse vestibule in recent years …

Recent studies have demonstrated that delivery of genes to the inner ear can achieve a
variety of effects ranging from support of auditory neuron survival to protection and …

Despite the significant impact of hearing and balance disorders on the general population
there are currently no dedicated pharmaceuticals that target the inner ear. Advances in …