Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer's disease

YJ Cheng, CH Lin, HY Lane - International Journal of Molecular Sciences, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

NMDA neurotransmission dysfunction in mild cognitive impairment and Alzheimer's disease

CH Lin, YJ Huang, CJ Lin, HY Lane… - Current pharmaceutical …, 2014 - ingentaconnect.com
The prevalence of Alzheimer's disease (AD) in the elderly is growing rapidly worldwide, and
the deteriorating clinical course of AD places a heavy burden on both the patients and their …

The dual role of glutamatergic neurotransmission in Alzheimer's disease: from pathophysiology to pharmacotherapy

VN Bukke, M Archana, R Villani, AD Romano… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Neurotransmitters in prevention and treatment of Alzheimer's disease

Z Yang, Y Zou, L Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of cognitive impairment in middle-aged
and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so …

Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease

Y Xu, J Yan, P Zhou, J Li, H Gao, Y Xia, Q Wang - Progress in neurobiology, 2012 - Elsevier
Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

Amyloid-β, tau, and the cholinergic system in Alzheimer's disease: Seeking direction in a tangle of clues

A Majdi, S Sadigh-Eteghad… - Reviews in the …, 2020 - degruyter.com
The link between histopathological hallmarks of Alzheimer's disease (AD), ie amyloid
plaques, and neurofibrillary tangles, and AD-associated cognitive impairment, has long …

Cognitive decline in neuronal aging and Alzheimer's disease: role of NMDA receptors and associated proteins

J Avila, M Llorens-Martín, N Pallas-Bazarra… - Frontiers in …, 2017 - frontiersin.org
Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity.
Here we discuss these alterations at the level of brain regions, brain cells, and brain …

Role of Aβ in Alzheimer's-related synaptic dysfunction

H Zhang, X Jiang, L Ma, W Wei, Z Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease

Z Guan - Acta Pharmacologica Sinica, 2008 - nature.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and its
pathogenesis is likely to be associated with multiple etiologies and mechanisms in which …