Rethinking cancer: current challenges and opportunities in cancer research

R Cagan, P Meyer - Disease models & mechanisms, 2017 - journals.biologists.com
Cancer therapeutics currently have the lowest clinical trial success rate of all major
diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon …

[HTML][HTML] Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma

R Tang, H Liu, Y Yuan, K Xie, P Xu, X Liu, J Wen - Oncotarget, 2017 - ncbi.nlm.nih.gov
Although the metabolic syndrome is a commonplace topic, its potential threats to public
health is a problem that cannot be neglected. As the living conditions improved significantly …

Genome-wide association studies in cancer—current and future directions

CC Chung, WCS Magalhaes… - …, 2010 - academic.oup.com
Genome-wide association studies (GWAS) have emerged as an important tool for
discovering regions of the genome that harbor genetic variants that confer risk for different …

Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management?

DH Roukos - Expert Review of Molecular Diagnostics, 2010 - Taylor & Francis
Elusion or inspired scientific reality? Personalized medicine could revolutionize cancer
management, if robust prognostic and predictive tools can be developed. However, there is …

Reverse cardio‐oncology: cancer development in patients with cardiovascular disease

JP Aboumsallem, J Moslehi… - Journal of the American …, 2020 - Am Heart Assoc
Overwhelming epidemiological evidence demonstrate that cardiovascular disease and
cancer represent major health burdens in the United States, and they are the leading causes …

Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies

L Qiao, D Ma, H Lv, D Shi, M Fei, Y Chen, F Xie… - Diabetology & metabolic …, 2020 - Springer
Abstract Background Metabolic syndrome (MetS) has been related to the pathogenesis of
variety categories of cancers. This meta-analysis aimed to determine the association …

A brief tour guide to cancer disease

P Bisoyi - Understanding cancer, 2022 - Elsevier
All multicellular organisms are made up of millions of cells. Under physiological conditions,
the cells usually behave in a specific biological manner to sustain a normal healthy life …

The role of genomics in global cancer prevention

O Ginsburg, P Ashton-Prolla, A Cantor… - Nature Reviews …, 2021 - nature.com
Despite improvements in the understanding of cancer causation, much remains unknown
regarding the mechanisms by which genomic and non-genomic factors initiate …

[HTML][HTML] Dose-response association between cardiovascular health and mortality in cancer survivors

R López-Bueno, L Yang, J Calatayud… - Current Problems in …, 2023 - Elsevier
Background There is little knowledge on the dose-response association between
cardiovascular health (CVH) and risk of all-cause, cardiovascular disease (CVD) and cancer …

Role of genetic susceptibility in development of treatment-related adverse outcomes in cancer survivors

S Bhatia - Cancer epidemiology, biomarkers & prevention, 2011 - AACR
Clear and unambiguous associations have been established between therapeutic
exposures and specific complications. However, considerable interindividual variability is …