Zhou et al. reply—A revised Correspondence by Forsberg et al. 1 (whose authors include
the founders of CRAY Innovation, LA Forsberg and JP Dumanski) posits that the …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood
lymphocytes is the first genotoxicity biomarker that has shown an association with cancer …

From the fertilization of an egg until the death of an individual, somatic cells can accumulate
genetic changes, such that cells from different tissues or even within the same tissue differ …

Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to
occur in normal tissue of individuals ascertained with varied phenotypes, indicating that …

The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …

Contrary to earlier beliefs, every cell in the individual is genetically different due to somatic
mutations. Consequently, tissues become a mixture of cells with distinct genomes, a …

Mutation is a fundamental process in tumorigenesis. However, the degree to which the rate
of somatic mutation varies across the human genome and the mechanistic basis underlying …

Clonal mosaicism arises when a postzygotic mutational event is detectable in
subpopulations of cells as an alternative genotype while not present in the germline …