[HTML][HTML] Genomic copy number variants in CML patients with the Philadelphia chromosome (Ph+): an update
H Zhang, M Liu, X Wang, Y Ren, YM Kim… - Frontiers in …, 2021 - frontiersin.org
Background Submicroscopic segmental imbalances detected by array-comparative genomic
hybridization (array-CGH) were discovered to be common in chronic myeloid leukemia …
hybridization (array-CGH) were discovered to be common in chronic myeloid leukemia …
Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has
been recently supported by the results of epidemiological studies that associated CA …
been recently supported by the results of epidemiological studies that associated CA …
Genomic copy number variation affecting genes involved in the cell cycle pathway: implications for somatic mosaicism
Somatic genome variations (mosaicism) seem to represent a common mechanism for
human intercellular/interindividual diversity in health and disease. However, origins and …
human intercellular/interindividual diversity in health and disease. However, origins and …
[HTML][HTML] A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
Background Mosaic loss of Y chromosome (LOY) is the most common somatic change that
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens
S Bonassi, L Hagmar, U Strömberg, AH Montagud… - Cancer Research, 2000 - AACR
An increased risk of cancer in healthy individuals with high levels of chromosomal
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …
Metabolic gene variants associated with chromosomal aberrations in healthy humans
K Hemminki, C Frank, A Försti, L Musak… - Genes …, 2015 - Wiley Online Library
Nonspecific chromosomal aberrations (CAs) are found in about 1% of lymphocytes drawn
from healthy individuals. They include chromosome‐type aberrations (CSAs), which are …
from healthy individuals. They include chromosome‐type aberrations (CSAs), which are …
[PDF][PDF] Large copy-number variants in UK Biobank caused by clonal hematopoiesis may confound penetrance estimates
Large copy-number variants (CNVs) are strongly associated with both developmental delay
and cancer, but the type of disease depends strongly on when and where the mutation …
and cancer, but the type of disease depends strongly on when and where the mutation …
Somatic mosaicism of sex chromosomes in the blood and brain
In the blood, mosaic somatic aneuploidy (mSA) of all chromosomes has been found to be
associated with adverse health outcomes, including hematological cancer. Sex …
associated with adverse health outcomes, including hematological cancer. Sex …
[HTML][HTML] Somatic mosaicism detected by exon-targeted, high-resolution aCGH in 10 362 consecutive cases
Somatic chromosomal mosaicism arising from post-zygotic errors is known to cause several
well-defined genetic syndromes as well as contribute to phenotypic variation in diseases …
well-defined genetic syndromes as well as contribute to phenotypic variation in diseases …
[HTML][HTML] Ontogenetic and pathogenetic views on somatic chromosomal mosaicism
Intercellular karyotypic variability has been a focus of genetic research for more than 50
years. It has been repeatedly shown that chromosome heterogeneity manifesting as …
years. It has been repeatedly shown that chromosome heterogeneity manifesting as …