Chromosomal aberrations (CAs) are thought to be integrative biomarkers that reflect
exposure to chromosome-damaging carcinogens and host factors. To investigate whether …

Mosaic loss of the X chromosome (mLOX) is the most common clonal somatic alteration in
leukocytes of female individuals,, but little is known about its genetic determinants or …

Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), and micronuclei (MN)
in peripheral blood lymphocytes have for decades been used as cytogenetic biomarkers to …

Current cytogenetics has largely focused its efforts on the identification of recurrent
karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale …

Deletions on the long-arm of chromosome 20, del (20q), are common karyotypic
abnormalities in myeloid disorders. Bioinformatic analyses of the B-allele frequency and log …

Although trisomy 8 as the sole chromosome aberration is the most common numerical
abnormality in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), little is …

Background Mosaic somatic alterations are present in all multi-cellular organisms, but the
physiological effects of low-level mosaicism are largely unknown. Most mosaic alterations …

Background Accurate protocols and methods to robustly detect the mosaic loss of
chromosome Y (mLOY) are needed given its reported role in cancer, several age-related …

Mosaicism, the presence of subpopulations of cells bearing somatic mutations, is associated
with disease and aging and has been detected in diverse tissues, including apparently …

Ample evidence exists for shared risk factors for genetic mosaicism and cancer risk as well
as abundant support linking genetic mosaicism in leukocytes to hematologic malignancies …