Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …

Latest technological advances have empowered researchers to systematically examine the
cancer genome at unprecedented resolution. Recent studies revealed that somatically …

Multiple studies have demonstrated the utility of chromosomal microarray (CMA) testing to
identify clinically significant copy number alterations (CNAs) and copy-neutral loss-of …

Background Recent genome-wide microarray-based research investigations have revealed
a high frequency of submicroscopic copy number alterations (CNAs) in the myelodysplastic …

Introduction Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic
chromosomal event in cancers; however, its underlying relationship with tumorigenesis is …

The technological progress of massively parallel sequencing (MPS) has triggered a
remarkable development in the research on postzygotic mutations. Although the …

Background Mosaic mutations contribute to numerous human disorders. As such, the
identification and precise quantification of mosaic mutations is essential for a wide range of …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Background Somatic mosaicism denotes the presence of genetically distinct populations of
somatic cells in one individual who has developed from a single fertilised oocyte. Mosaicism …

Genomic mosaicism arising from postzygotic mutations has long been associated with
cancer and more recently with non-cancer diseases. It has also been detected in healthy …