Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Hematol Oncol Clin N Am 34 (2020) 357–367 https://doi. org/10.1016/j. hoc. 2019.11. 006
hemonc. theclinics. com 0889-8588/20/© 2019 Elsevier Inc. All rights reserved. phenotype …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Clonal hematopoiesis (CH) describes an asymptomatic expansion of blood cells descended
from a single hematopoietic stem cell. Recent studies have shown that CH increases in …

Acquired genetic mutations in hematopoietic stem or progenitor cells can lead to clonal
expansion and imbalanced blood cell production. Clonal hematopoiesis is exceptionally …

Clonal hematopoiesis (CH) mutations are common among individuals without known
hematologic disease. CH mutations have been associated with numerous adverse clinical …

Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid
malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting …

Somatic mutations are an unavoidable consequence of aging tissues. Even though most
mutations are functionally silent, some may affect genes critical to proper tissue self-renewal …

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Clonal hematopoiesis (CH) describes somatic mutations in hematopoietic stem and
progenitor cells resulting in clonal expansion in individuals with no overt hematologic …