Publisher Summary The proliferation of smooth muscle cells is thought to be a key event in
the development of atherosclerotic lesions and is involved in the restenosis of arteries. To …

Smooth muscle cell (SMC) proliferation is a key event in atherosclerosis and in the
restenosis of arteries after angioplasty. We and colleagues in many other laboratories have …

For a general survey of the atherosclerotic process, the reader is referred to recent reviews.
34-37 In the early stages of the disease, smooth muscle cells migrate from the media to the …

A long-term objective of my laboratory has been to understand the mechanisms that regulate
both normal and developmental growth of vascular smooth muscle as well as the …

Platelets are important in acute thrombotic occlusion of injured vessels, eg, subsequent to
angioplasty. In contrast to these acute events of thrombus formation, much less is known …

In previous experiments (Grotendorst et al, 1981), we showed that platelet-derived growth
factor promotes the migration of smooth muscle cells in vitro. Using a “checkerboard” …

The smooth muscle cells (SMC) of the blood vessel wall are normally present in a relatively
quiescent stale. However, arterial injury or vascular disease induces a proliferative response …

Arterial structural changes play a key role in atherosclerosis and hypertension and could
become a valid target for pharmacotherapy of these disorders. Current insights in arterial …

The migration and proliferation of smooth muscle cells (SMCs) within the intima of arteries
following mechanical injury is thought to be initiated by vessel wall injury and release of …

Proliferation of vascular smooth-muscle cells occurs during the development of
atherosclerosis and the remodeling of arteries that accompanies chronic systemic or …