Athersclerosis is characterized by progressive arterial stenosis of the major vessels of the
systemic circulation. In man, atherosclerotic lesions are composed principally of smooth …

There is considerable interest in the cellular mechanisms responsible for the accelerated
smooth muscle growth in arteries from hypertensive patients' and animals. 2.3 This interest …

Smooth muscle cells and connective tissue produced by these cells are the main
constituents of early atherosclerotic lesions. As smooth muscle cells become engaged in …

Smooth muscle proliferation has been recognized as central to the pathology of both major
forms of vascular disease: atherosclerosis and hypertension. Recent advances in our …

Agents which promote vascular smooth muscle cell (SMC) proliferation are still unknown
and cannot be readily defined in vivo. To examine this problem, we have developed a …

The current state of our knowledge of the control of endothelial growth and the role of
endothelial injury in the pathogenesis of atherosclerosis can be summarized as follows: 1 …

Arterial injury induces vascular smooth muscle cells (VSMC) to modulate from a quiescent to
a proliferative state characterized by cell division, migration, and secretion of matrix. These …

Proliferation of smooth muscle cells (SMC) in the arterial intima of man and experimental
animals is important in the pathogenesis of atherosclerosis. Vascular SMC proliferation in …

This article reviews the proliferative, structural and synthetic behaviour of vascular smooth
muscle cells under a variety of conditions. It shows how some experimental procedures …