DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …

Cardiac hypertrophy produced by treatment with thyroxine for 7 days was accompanied by a
significant increase in polyamine content. Putrescine was elevated by 4-to 5-fold …

Treatment with thyroxine for 7 days to produce myocardial hypertrophy led to an increase in
the content of putrescine, spermidine, and spermine in the rat heart. The content of …

Objective: Ornithine decarboxylase (ODC) is an initial rate-limiting enzyme in the synthesis
of polyamines (putrescine, spermidine, and spermine) that play a role in cell growth and …

To evaluate the role of polyamine biosynthesis in myocardial growth, the activity of ornithine
decarboxylase (ODC) and the levels of the polyamines, spermidine, spermine, and …

Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …

Isoprenaline stimulated increases in ornithine decarboxylase activity and polyamine content
in cardiac tissues are implicated in macromolecular synthesis and cellular growth, but little is …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …

Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …