AD− 1 small molecule improves learning and memory function in scopolamine-induced amnesic mice model through regulation of CREB/BDNF and NF-κB/MAPK …

R Balakrishnan, JY Park, DY Cho, JY Ahn, DS Yoo… - Antioxidants, 2023 - mdpi.com
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …

Chinese herbal extracts exert neuroprotective effect in Alzheimer's disease mouse through the dopaminergic synapse/apoptosis signaling pathway

Q Huang, C Zhang, S Qu, S Dong, Q Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) as an age-related, irreversible neurodegenerative
disease, characterized by cognitive dysfunction, has become progressively serious with a …

Sodium tanshinone IIA sulfonate attenuates scopolamine‐induced cognitive dysfunctions via improving cholinergic system

QQ Xu, YJ Xu, C Yang, Y Tang, L Li… - BioMed research …, 2016 - Wiley Online Library
Sodium Tanshinone IIA sulfonate (STS) is a derivative of Tanshinone IIA (Tan IIA). Tan IIA
has been reported to possess neuroprotective effects against Alzheimer's disease (AD) …

Danshensu attenuates scopolamine and amyloid-β-induced cognitive impairments through the activation of PKA-CREB signaling in mice

HJ Bae, K Sowndhararajan, HB Park, SY Kim… - Neurochemistry …, 2019 - Elsevier
Alzheimer's disease (AD) is an important chronic neurodegenerative disorder and is mainly
associated with cognitive dysfunction. At present, bioactive compounds from traditional …

Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model

T Muhammad, T Ali, M Ikram, A Khan, SI Alam… - Journal of Neuroimmune …, 2019 - Springer
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …

Friedelin attenuates neuronal dysfunction and memory impairment by inhibition of the activated JNK/NF-κB signalling pathway in scopolamine-induced mice model of …

M Sandhu, HM Irfan, SA Shah, M Ahmed, I Naz… - Molecules, 2022 - mdpi.com
Oxidative stress (OS) and c-Jun N-terminal kinase (JNK) are both key indicators implicated
in neuro-inflammatory signalling pathways and their respective neurodegenerative …

Phytochemical allylguaiacol exerts a neuroprotective effect on hippocampal cells and ameliorates scopolamine-induced memory impairment in mice

HS Lim, BY Kim, YJ Kim, SJ Jeong - Behavioural Brain Research, 2018 - Elsevier
Allylguaiacol is a phytochemical occurring in various plants such as cloves, cinnamon, basil,
and nutmeg. Pharmacological effects of allylguaiacol include antimicrobial, anti …

Analogous β-carboline alkaloids harmaline and harmine ameliorate scopolamine-induced cognition dysfunction by attenuating acetylcholinesterase activity, oxidative …

SP Li, YW Wang, SL Qi, YP Zhang, G Deng… - Frontiers in …, 2018 - frontiersin.org
The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a
variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity …

Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling …

B Lian, J Gu, C Zhang, Z Zou, M Yu, F Li, X Wu… - Metabolic Brain …, 2022 - Springer
Background Isofraxidin is a coumarin compound mainly isolated from several traditional and
functional edible plants beneficial for neurodegenerative diseases, including Sarcandra …

Neuroprotective effect of Saroglitazar on scopolamine-induced Alzheimer's in rats: insights into the underlying mechanisms

G Sandeep Ganesh, P Konduri, AS Kolusu… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD) is one of the most prevalent and progressive neurodegenerative
disorders, hallmarked by increased amyloid-β deposition and enhanced oxidative load in …