Role of inflammation and oxidative stress in the pathology of ageing in COPD: potential therapeutic interventions
G Choudhury, W MacNee - COPD: Journal of Chronic Obstructive …, 2017 - Taylor & Francis
Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive
phase of life is complete, which is thought to arise because of impaired DNA repair following …
phase of life is complete, which is thought to arise because of impaired DNA repair following …
Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD
E Barreiro, C Fermoselle, M Mateu-Jimenez… - Free Radical Biology …, 2013 - Elsevier
Respiratory conditions such as chronic obstructive pulmonary disease (COPD) are
associated with a greater risk for lung cancer (LC). Oxidative stress and inflammation are …
associated with a greater risk for lung cancer (LC). Oxidative stress and inflammation are …
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
H Yao, I Rahman - Toxicology and applied pharmacology, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …
Oxidative stress in COPD
PA Kirkham, PJ Barnes - Chest, 2013 - Elsevier
Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …
The role of oxidative stress in the pathogenesis of COPD: implications for therapy
I Rahman - Treatments in respiratory medicine, 2005 - Springer
Chronic inflammation and oxidative stress are important features in the pathogenesis of
COPD. The increased oxidative stress in patients with COPD is the result of an increased …
COPD. The increased oxidative stress in patients with COPD is the result of an increased …
Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
W MacNee, I Rahman - Trends in molecular medicine, 2001 - cell.com
There is now considerable evidence for an increased oxidant burden in patients with chronic
obstructive pulmonary disease (COPD). Oxidative stress is a critical feature in the …
obstructive pulmonary disease (COPD). Oxidative stress is a critical feature in the …
Oxidative stress and free radicals in COPD–implications and relevance for treatment
W Domej, K Oettl, W Renner - International journal of chronic …, 2014 - Taylor & Francis
Oxidative stress occurs when free radicals and other reactive species overwhelm the
availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and …
availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and …
Oxidant metabolism in chronic obstructive pulmonary disease
The development and progression of chronic obstructive pulmonary disease (COPD) have
been associated with increased oxidative stress or reduced antioxidant resources. Several …
been associated with increased oxidative stress or reduced antioxidant resources. Several …
Lung epithelium damage in COPD–an unstoppable pathological event?
Chronic obstructive pulmonary disease (COPD) is a common term for alveolar septal wall
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …