Role of inflammation and oxidative stress in the pathology of ageing in COPD: potential therapeutic interventions

G Choudhury, W MacNee - COPD: Journal of Chronic Obstructive …, 2017 - Taylor & Francis
Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive
phase of life is complete, which is thought to arise because of impaired DNA repair following …

Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD

E Barreiro, C Fermoselle, M Mateu-Jimenez… - Free Radical Biology …, 2013 - Elsevier
Respiratory conditions such as chronic obstructive pulmonary disease (COPD) are
associated with a greater risk for lung cancer (LC). Oxidative stress and inflammation are …

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

H Yao, I Rahman - Toxicology and applied pharmacology, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …

Oxidative stress in COPD

PA Kirkham, PJ Barnes - Chest, 2013 - Elsevier
Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …

The role of oxidative stress in the pathogenesis of COPD: implications for therapy

I Rahman - Treatments in respiratory medicine, 2005 - Springer
Chronic inflammation and oxidative stress are important features in the pathogenesis of
COPD. The increased oxidative stress in patients with COPD is the result of an increased …

Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?

W MacNee, I Rahman - Trends in molecular medicine, 2001 - cell.com
There is now considerable evidence for an increased oxidant burden in patients with chronic
obstructive pulmonary disease (COPD). Oxidative stress is a critical feature in the …

Oxidative stress and free radicals in COPD–implications and relevance for treatment

W Domej, K Oettl, W Renner - International journal of chronic …, 2014 - Taylor & Francis
Oxidative stress occurs when free radicals and other reactive species overwhelm the
availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and …

Oxidant metabolism in chronic obstructive pulmonary disease

AW Boots, G Haenen, A Bast - European Respiratory Journal, 2003 - Eur Respiratory Soc
The development and progression of chronic obstructive pulmonary disease (COPD) have
been associated with increased oxidative stress or reduced antioxidant resources. Several …

Lung epithelium damage in COPD–an unstoppable pathological event?

S Hadzic, CY Wu, S Avdeev, N Weissmann… - Cellular signalling, 2020 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a common term for alveolar septal wall
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …

Antioxidant therapeutic targets in COPD

I Rahman, I Kilty - Current Drug Targets, 2006 - ingentaconnect.com
Oxidative stress and chronic inflammation are important features in the pathogenesis of
chronic obstructive pulmonary disease (COPD). Oxidative stress has important …