Targeting of acetylcholinesterase to lipid rafts of muscle

MT Moral-Naranjo, MF Montenegro… - Chemico-biological …, 2008 - Elsevier
Despite the great progress made in setting the basis for the molecular diversity of
acetylcholinesterase (AChE), an explanation for the existence of two types of amphiphilic …

[HTML][HTML] The levels of both lipid rafts and raft-located acetylcholinesterase dimers increase in muscle of mice with muscular dystrophy by merosin deficiency

MT Moral-Naranjo, MF Montenegro… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Wild type and dystrophic (merosin-deficient) Lama2dy mice muscles were compared for
their density of lipid rafts. The 5-fold higher level of caveolin-3 and the 2-3 times higher level …

Lipid rafts of mouse liver contain nonextended and extended acetylcholinesterase variants along with M3 muscarinic receptors

MF Montenegro, J Cabezas‐Herrera… - The FASEB …, 2017 - Wiley Online Library
The observation of acetylcholinesterase (AChE) type H (AChEH), which is the predominant
AChE variant in visceral organs and immune cells, in lipid rafts of muscle supports functional …

Rafts are required for acetylcholine receptor clustering.

F Stetzkowski-Marden, M Recouvreur… - Journal of molecular …, 2006 - europepmc.org
Cholesterol-sphingolipid microdomains, or lipid rafts, are major regulators of molecular
interactions in membrane organization. Because lipid rafts can move laterally and cluster …

Role of lipid rafts in agrin-elicited acetylcholine receptor clustering

C Pato, F Stetzkowski-Marden, K Gaus… - Chemico-biological …, 2008 - Elsevier
Emerging concepts of membrane organization point to the compartmentalization of the
plasma membrane into distinct lipid microdomains. This lateral segregation within cellular …

Coated vesicles from developing and adult rat skeletal muscles contain multiple molecular forms of acetylcholinesterase

CA Hodges‐Savola, EJ Gregory… - Journal of …, 1989 - Wiley Online Library
The main purpose of this work was to determine which of the multiple isoforms of
acetylcholinesterase (AChE) are associated with clathrin‐coated vesicles (CVs) from …

Glycosylation of Acetylcholinesterase Forms in Microsomal Membranes from Normal and Dystrophic Lama2dy Mouse Muscle

J Cabezas‐Herrera, MT Moral‐Naranjo… - Journal of …, 1997 - Wiley Online Library
The distribution and glycosylation of acetylcholinesterase (AChE) forms in vesicles derived
from sarcoplasmic reticulum of normal muscle (NMV) were investigated and compared with …

Agrin triggers the clustering of raft‐associated acetylcholine receptors through actin cytoskeleton reorganization

A Cartaud, F Stetzkowski‐Marden, A Maoui… - Biology of the …, 2011 - Wiley Online Library
Background information. Cholesterol/sphingolipid‐rich membrane microdomains or
membrane rafts have been implicated in various aspects of receptor function such as …

Muscular dystrophy by merosin deficiency decreases acetylcholinesterase activity in thymus of Lama2dy mice

S Nieto‐Cerón, LFS Del Campo… - Journal of …, 2005 - Wiley Online Library
Half of congenital muscular dystrophy cases arise from laminin α2 (merosin) deficiency, and
merosin‐deficient mice (Lama2dy) exhibit a dystrophic phenotype. The abnormal …

Targeting acetylcholinesterase to the neuromuscular synapse

RL Rotundo, SG Rossi, LM Kimbell, C Ruiz… - Chemico-biological …, 2005 - Elsevier
The collagen-tailed form of acetylcholinesterase (ColQ-AChE) is the major if not unique form
of the enzyme associated with the specialized synaptic basal lamina at the neuromuscular …