Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through …

R Shukla, S Pahal, A Gupta, P Choudhary… - Journal of …, 2023 - Taylor & Francis
Microorganisms in human gastrointestinal tract have profound influence on the
transformation of food into metabolites which can impact human health. Along with playing …

Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder

S Pahal, A Gupta, P Choudhary… - Journal of …, 2022 - Taylor & Francis
Neurodegenerative disorders are illnesses that are responsible for neuronal cell death and
resulting in lifelong cognitive problems. Due to their unclear mechanism, there are no …

Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid …

M Zaka, SA Sehgal, S Shafique, BH Abbasi - Journal of Molecular Graphics …, 2017 - Elsevier
From last decade, there has been progressive improvement in computational drug
designing. Several diseases are being cured from different plant extracts and products …

Withanolides from Withania somnifera as an immunity booster and their therapeutic options against COVID-19

P Khanal, R Chikhale, YN Dey, I Pasha… - Journal of …, 2022 - Taylor & Francis
Traditionally, Withania somnifera is widely used as an immune booster, anti-viral, and for
multiple medicinal purposes. The present study investigated the withanolides as an immune …

Network pharmacology of Withania somnifera against stress associated neurodegenerative diseases

T Duyu, P Khanal, YN Dey, SK Jha - Advances in Traditional Medicine, 2021 - Springer
Withania somnifera is a Rasayana of the Ayurvedic system of medicine that is widely used to
treat stress-related neurological disorders. Although its anti-stress activity is reported in …

[HTML][HTML] A Multi-Target mechanism of Withania somnifera bioactive compounds in autism spectrum disorder (ASD) Treatment: Network pharmacology, molecular …

SM Alqahtani - Arabian Journal of Chemistry, 2024 - Elsevier
Autism spectrum disorder (ASD) is a developmental disorder resulting from variations in
brain structure and function. Individuals with ASD often experience challenges in …

Identification of potential inhibitors of PARP-1, a regulator of caspase-independent cell death pathway, from Withania somnifera phytochemicals for combating neurotoxicity: A …

S Mukherjee, G Kumar, R Patnaik - Journal of Theoretical and …, 2017 - World Scientific
Poly (ADP-ribose) polymerase-1 (PARP-1) reverses DNA damage by repairing DNA nicks
and breaks in the normal cellular environment. However, during abnormal conditions like …

In-silico validation of novel therapeutic activities of withaferin a using molecular docking and dynamics studies

R Surya Ulhas, A Malaviya - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Withaferin A is a bioactive molecule of W. somnifera. We access its efficacy against various
target proteins associated with Cancer, Type-II Diabetes and hypercholesterolemia using …

In-silico studies of phytoconstituents of Bacopa monnieri and Centella asiatica with crystal structure of myelin oligodendrocyte glycoprotein against primary …

A Gupta, A Roy, V Raja, S Rustagi… - Journal of Integrated …, 2024 - pubs.thesciencein.org
There is a rapid spread of Multiple Sclerosis disorder across the globe. There are around 2.8
million cases of Multiple Sclerosis in the world; among them, 1 million are just present in the …

Analysis of medicinal and therapeutic potential of Withania somnifera derivatives against COVID-19

SZ Gheshlaghi, E Nakhaei, A Ebrahimi… - Journal of …, 2023 - Taylor & Francis
Apart from chemical and allopathic drugs, several medicinal plants contain phytochemicals
that are potentially useful to counter the COVID-19 pandemic. Withania somnifera …