In the mammalian auditory system, sensory cell loss resulting from aging, ototoxic drugs,
infections, overstimulation and other causes is irreversible and leads to permanent …

Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical
impulses that subserve audition,. Loss of hair cells and their innervating neurons is the most …

Although hair cells regenerate spontaneously in birds and lower vertebrates following injury,
there is yet no effective way to stimulate hair cell regeneration in mature mammalian inner …

The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural
hearing loss. This study aimed to promote the regeneration of sensory hair cells in the …

Hearing impairment due to the loss of sensory hair cells is permanent in humans.
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

Therapies for the protection and regeneration of auditory hair cells are of great interest given
the significant monetary and lifestyle impact of hearing loss. The past decade has seen …

The hallmark of mechanosensory hair cells is the stereocilia, where mechanical stimuli are
converted into electrical signals. These delicate stereocilia are susceptible to acoustic …

For mammalian cochlear hair cells, fate determination is normally completed by birth. We
report here that overexpression of Math1, a mouse homolog of the Drosophila gene atonal …

Following hair cell elimination in severely traumatized cochleae, differentiated supporting
cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 …