Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments
(TMEs). Inspired by its high intratumoral level (5–20 µmol g− 1), a novel treatment paradigm …

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in
tumors holds great promise for the reversal of the immunosuppressive tumor …

The increasing evidence supports the fact that lactate in the tumor microenvironment (TME)
plays a vital role in tumor proliferation, metastasis, and recurrence, which in turn is emerging …

The excessive lactate in the tumor microenvironment always leads to poor therapeutic
outcomes of chemotherapy. In this study, a self-driven bioreactor (defined as SO@ MDH …

Regulating the tumor microenvironment (TME) has been a promising strategy to improve
antitumor therapy. Here, a red blood cell membrane (mRBC)‐camouflaged hollow MnO2 …

Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …

Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives
immunosuppression and promotes tumor progression. Material‐engineered strategies for …

The aggressive proliferation of tumor cells often requires increased glucose uptake and
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …

In this study, a bacterium-based lactate bioconsumer (designated Bac@ RFH) was
elaborately engineered for persistent lactate consumption to potentiate antitumor …

In the immunosuppressive tumor microenvironment (iTME), lactate secretion by cancer cells
facilitates cell escape via M1 to M2 macrophage polarization, and T cell exhaustion …