Natural killer cells as a double-edged sword in cancer immunotherapy: A comprehensive review from cytokine therapy to adoptive cell immunotherapy

Y Wu, J Li, PJ Kaboli, J Shen, X Wu, Y Zhao, H Ji… - Pharmacological …, 2020 - Elsevier
Natural killer (NK) cells are immune cells which are able to kill tumor and virus-infected cells
and play an important role in both innate immunity and acquired immunity. Tumor …

Innate lymphoid cells in normal and disease: An introductory overview

L Moretta, F Locatelli - Immunology letters, 2016 - Elsevier
Innate lymphoid cells (ILC) represent a novel group of lymphocytes that, different from T and
B-lymphocytes lack recombinant activating genes (RAG-1 or RAG-2) and thus do not …

Targeting natural killer cells and natural killer T cells in cancer

E Vivier, S Ugolini, D Blaise, C Chabannon… - Nature Reviews …, 2012 - nature.com
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer

M Sabry, MW Lowdell - Stem Cells Translational Medicine, 2020 - academic.oup.com
Adoptive cell therapy (ACT) is an approach to cancer treatment that involves the use of
antitumor immune cells to target residual disease in patients after completion of …

[HTML][HTML] Natural killer cell dysfunction in cancer and new strategies to utilize NK cell potential for cancer immunotherapy

W Zhang, Z Zhao, F Li - Molecular Immunology, 2022 - Elsevier
The continuous, in-depth exploration of the occurrence and development of cancer has
shown that immune cell dysfunction is closely associated with tumor progression and poor …

The influence of macrophages and the tumor microenvironment on natural killer cells

T Krneta, A Gillgrass, AA Ashkar - Current Molecular Medicine, 2013 - ingentaconnect.com
Numerous reviews in the field of NK cell biology dictate the pivotal role that NK cells play in
tumor rejection. Although these cell types were originally described based on their cytotoxic …

Multiple defects of natural killer cells in cancer patients: anarchy, dysregulated systemic immunity, and immunosuppression in metastatic cancer

A Jewett, J Kos, K Kaur, TL Turnsek… - Critical Reviews™ in …, 2020 - dl.begellhouse.com
We have previously demonstrated that natural killer (NK) cells are the main immune
effectors that can mediate selection and differentiation of different cancer stem cells and …

NK and NKT cell-mediated immune surveillance against hematological malignancies

K Shimizu, T Iyoda, S Yamasaki, N Kadowaki, A Tojo… - Cancers, 2020 - mdpi.com
Recent cancer treatment modalities have been intensively focused on immunotherapy. The
success of chimeric antigen receptor T cell therapy for treatment of refractory B cell acute …

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

A Arina, O Murillo, J Dubrot, A Azpilikueta… - Expert opinion on …, 2007 - Taylor & Francis
There is compelling evidence for the role of natural killer (NK) cells in tumor
immunosurveillance and their beneficial effects on many experimentally successful …

Immune circuits to shape natural killer cells in cancer

I Mattiola - Cancers, 2021 - mdpi.com
Simple Summary Natural killer (NK) cells are circulating innate lymphocytes endowed with
antitumoral functions. NK cells are the innate counterpart of effector T cells and among the …