Secretory mucin MUC5AC is an extensively glycosylated high molecular weight protein that
forms a polymeric gel layer over the epithelial layers under physiological conditions, to …

The human mucin gene MUC4 is overexpressed in pancreatic cancer and cancer cell lines,
while remaining undetectable in the normal pancreas, indicating its important role in …

Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma
(PDAC) progression and metastasis. However, knowledge of the contribution of MUC16 to …

Pancreatic cancer remains a lethal malignancy with poor prognosis owing to therapeutic
resistance, frequent recurrence and the absence of treatment strategies that specifically …

MUC1-C overexpression has been associated with the progression of pancreatic tumors by
promoting the aggressive and metastatic phenotypes. As MUC1 is a STAT3 target gene …

Patients with pancreatic neuroendocrine tumors (pNETs) have limited access to effective
targeted agents and invariably succumb to progressive disease. MUC1-C is a druggable …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a
late diagnosis, poor survival, and limited treatment options. Over the past two decades …

MUC4 is a type I membrane-bound mucin expressed at the apical pole of normal polarized
epithelial cells. MUC4 apomucin is characterized by a long hyperglycosylated extracellular …

Alterations in the expression of mucin family members play an important role as well as
alterations in oncogenes and onco-suppressor genes in carcinogenesis and progression of …

Abstract Mucin 1 (MUC1) is a heterodimeric protein formed by two subunits that is aberrantly
overexpressed in human breast cancer and other cancers. Historically, much of the early …