[HTML][HTML] Linking myometrial physiology to intrauterine pressure; how tissue-level contractions create uterine contractions of labor

RC Young, P Barendse - PLoS computational biology, 2014 - journals.plos.org
The mechanisms used to coordinate uterine contractions are not known. We develop a new
model based on the proposal that there is a maximum distance to which action potentials …

Synchronization of regional contractions of human labor; direct effects of region size and tissue excitability

RC Young - Journal of biomechanics, 2015 - Elsevier
The mechanisms used to coordinate organ-level contractions of human labor are not
universally accepted. We previously proposed a dual mechanism, where electrical activity …

[HTML][HTML] Mechanotransduction mechanisms for coordinating uterine contractions in human labor

RC Young - Reproduction, 2016 - rep.bioscientifica.com
This review presents evolving concepts of how the human uterus contracts in pregnancy,
with emphasis on the mechanisms of long-distance signaling. Action potential propagation …

A model and simulation of uterine contractions

AL Cochran, Y Gao - Mathematics and Mechanics of Solids, 2015 - journals.sagepub.com
We present a model of uterine contractions that consists of tissue mechanics, electrical
activity, and intrauterine pressure. Uterine contractions were simulated to measure the …

[HTML][HTML] A Computational Model of the Ionic Currents, Ca2+ Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle

WC Tong, CY Choi, S Karche, AV Holden, H Zhang… - PloS one, 2011 - journals.plos.org
Uterine contractions during labor are discretely regulated by rhythmic action potentials (AP)
of varying duration and form that serve to determine calcium-dependent force production …

Multi-scale and multi-physics model of the uterine smooth muscle with mechanotransduction

M Yochum, J Laforêt, C Marque - Computers in biology and medicine, 2018 - Elsevier
Preterm labor is an important public health problem. However, the efficiency of the uterine
muscle during labor is complex and still poorly understood. This work is a first step towards a …

Tissue-Level Signaling and Control of Uterine Contractility: The Action Potential—Calcium Wave Hypothesis

RC Young - The Journal of the Society for Gynecologic …, 2000 - Springer
This article describes the action potential—calcium wave hypothesis of uterine contractility.
Two known mechanisms of intercellular tissue-level signaling are merged into a single …

A computer model of uterine contractions based on action potential propagation and intercellular calcium waves

RC Young - Obstetrics & Gynecology, 1997 - Elsevier
OBJECTIVE: To simulate a uterine contraction using a novel computer model for uterine
communication and to validate the assumptions of the computer model by comparing the …

Simulating uterine contraction by using an electro-chemo-mechanical model

B Sharifimajd, CJ Thore, J Stålhand - Biomechanics and modeling in …, 2016 - Springer
Contractions of uterine smooth muscle cells consist of a chain of physiological processes.
These contractions provide the required force to expel the fetus from the uterus. The …

Emergent behaviors in a deterministic model of the human uterus

M Barclay, H Andersen, C Simon - Reproductive Sciences, 2010 - Springer
The human birth process is powered by uterine contractions that have observable patterns
that depend on the physiology of muscular activity. We explored a previously designed …