[HTML][HTML] Linking myometrial physiology to intrauterine pressure; how tissue-level contractions create uterine contractions of labor
RC Young, P Barendse - PLoS computational biology, 2014 - journals.plos.org
The mechanisms used to coordinate uterine contractions are not known. We develop a new
model based on the proposal that there is a maximum distance to which action potentials …
model based on the proposal that there is a maximum distance to which action potentials …
Synchronization of regional contractions of human labor; direct effects of region size and tissue excitability
RC Young - Journal of biomechanics, 2015 - Elsevier
The mechanisms used to coordinate organ-level contractions of human labor are not
universally accepted. We previously proposed a dual mechanism, where electrical activity …
universally accepted. We previously proposed a dual mechanism, where electrical activity …
[HTML][HTML] Mechanotransduction mechanisms for coordinating uterine contractions in human labor
RC Young - Reproduction, 2016 - rep.bioscientifica.com
This review presents evolving concepts of how the human uterus contracts in pregnancy,
with emphasis on the mechanisms of long-distance signaling. Action potential propagation …
with emphasis on the mechanisms of long-distance signaling. Action potential propagation …
A model and simulation of uterine contractions
AL Cochran, Y Gao - Mathematics and Mechanics of Solids, 2015 - journals.sagepub.com
We present a model of uterine contractions that consists of tissue mechanics, electrical
activity, and intrauterine pressure. Uterine contractions were simulated to measure the …
activity, and intrauterine pressure. Uterine contractions were simulated to measure the …
[HTML][HTML] A Computational Model of the Ionic Currents, Ca2+ Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle
WC Tong, CY Choi, S Karche, AV Holden, H Zhang… - PloS one, 2011 - journals.plos.org
Uterine contractions during labor are discretely regulated by rhythmic action potentials (AP)
of varying duration and form that serve to determine calcium-dependent force production …
of varying duration and form that serve to determine calcium-dependent force production …
Multi-scale and multi-physics model of the uterine smooth muscle with mechanotransduction
Preterm labor is an important public health problem. However, the efficiency of the uterine
muscle during labor is complex and still poorly understood. This work is a first step towards a …
muscle during labor is complex and still poorly understood. This work is a first step towards a …
Tissue-Level Signaling and Control of Uterine Contractility: The Action Potential—Calcium Wave Hypothesis
RC Young - The Journal of the Society for Gynecologic …, 2000 - Springer
This article describes the action potential—calcium wave hypothesis of uterine contractility.
Two known mechanisms of intercellular tissue-level signaling are merged into a single …
Two known mechanisms of intercellular tissue-level signaling are merged into a single …
A computer model of uterine contractions based on action potential propagation and intercellular calcium waves
RC Young - Obstetrics & Gynecology, 1997 - Elsevier
OBJECTIVE: To simulate a uterine contraction using a novel computer model for uterine
communication and to validate the assumptions of the computer model by comparing the …
communication and to validate the assumptions of the computer model by comparing the …
Simulating uterine contraction by using an electro-chemo-mechanical model
Contractions of uterine smooth muscle cells consist of a chain of physiological processes.
These contractions provide the required force to expel the fetus from the uterus. The …
These contractions provide the required force to expel the fetus from the uterus. The …
Emergent behaviors in a deterministic model of the human uterus
M Barclay, H Andersen, C Simon - Reproductive Sciences, 2010 - Springer
The human birth process is powered by uterine contractions that have observable patterns
that depend on the physiology of muscular activity. We explored a previously designed …
that depend on the physiology of muscular activity. We explored a previously designed …
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