Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

J Zhang, C Ji, H Zhang, H Shi, F Mao, H Qian, W Xu… - Science …, 2022 - science.org
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

J Wang, W Tang, M Yang, Y Yin, H Li, F Hu, L Tang… - Biomaterials, 2021 - Elsevier
Clinical treatment of malignant glioma remains a major challenge due to high infiltrative
growth and chemotherapeutic resistance of tumors and the presence of the blood brain …

Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors

SC Jang, OY Kim, CM Yoon, DS Choi, TY Roh, J Park… - ACS …, 2013 - ACS Publications
Exosomes, the endogenous nanocarriers that can deliver biological information between
cells, were recently introduced as new kind of drug delivery system. However, mammalian …

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

H Gomari, M Forouzandeh Moghadam… - OncoTargets and …, 2018 - Taylor & Francis
Purpose Exosomes are small 30–100 nm vesicles secreted by various cell types. They are
released by most cell types, indicating their important role in physiological and pathological …

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

S Rayamajhi, TDT Nguyen, R Marasini, S Aryal - Acta biomaterialia, 2019 - Elsevier
Extracellular vesicles (EVs) are phospholipid and protein constructs which are continuously
secreted by cells in the form of smaller (30–200 nm) and larger (micron size) particles. While …

Exosomes: cell-derived nanoplatforms for the delivery of cancer therapeutics

H Kim, EH Kim, G Kwak, SG Chi, SH Kim… - International journal of …, 2020 - mdpi.com
Exosomes are cell-secreted nanovesicles that naturally contain biomolecular cargoes such
as lipids, proteins, and nucleic acids. Exosomes mediate intercellular communication …

Blood exosomes endowed with magnetic and targeting properties for cancer therapy

H Qi, C Liu, L Long, Y Ren, S Zhang, X Chang, X Qian… - ACS …, 2016 - ACS Publications
Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously
by mammalian cells. Clinical applications for exosomes remain a challenge because of their …

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Q Yang, S Li, H Ou, Y Zhang, G Zhu, S Li… - Journal of …, 2024 - Springer
Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

[HTML][HTML] Bioinspired cell-derived nanovesicles versus exosomes as drug delivery systems: a cost-effective alternative

WJ Goh, S Zou, WY Ong, F Torta, AF Alexandra… - Scientific reports, 2017 - nature.com
Abstract Cell Derived Nanovesicles (CDNs) have been developed from the rapidly
expanding field of exosomes, representing a class of bioinspired Drug Delivery Systems …