We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …

Expression profiling using DNA microarrays holds great promise for a variety of research
applications, including the systematic characterization of genes discovered by sequencing …

Recent work has shown that copy number polymorphism is an important class of genetic
variation in human genomes,,,. Here we report a new method that uses SNP genotype data …

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Mosaicism is defined as the coexistence of cells with different genetic composition within an
individual, caused by postzygotic somatic mutation. Although somatic mosaicism for …

Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …

The identification of somatic driver mutations in cancer has enabled therapeutic advances
by identifying drug targets critical to disease causation. However, such genomic discoveries …

Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization
of these DNA copy-number changes is important for both the basic understanding of cancer …

The extent to which the biology of oncogenesis and ageing are shaped by factors that
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …