Detectable clonal mosaicism from birth to old age and its relationship to cancer
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …
wide association studies, we observed large chromosomal abnormalities in a subset of …
Widespread aneuploidy revealed by DNA microarray expression profiling
TR Hughes, CJ Roberts, H Dai, AR Jones, MR Meyer… - Nature …, 2000 - nature.com
Expression profiling using DNA microarrays holds great promise for a variety of research
applications, including the systematic characterization of genes discovered by sequencing …
applications, including the systematic characterization of genes discovered by sequencing …
A high-resolution survey of deletion polymorphism in the human genome
Recent work has shown that copy number polymorphism is an important class of genetic
variation in human genomes,,,. Here we report a new method that uses SNP genotype data …
variation in human genomes,,,. Here we report a new method that uses SNP genotype data …
A pan-tissue survey of mosaic chromosomal alterations in 948 individuals
Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …
single-nucleotide variants have been well characterized in the human body, the patterns …
[HTML][HTML] Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
B Rodríguez-Santiago, N Malats, N Rothman… - The American Journal of …, 2010 - cell.com
Mosaicism is defined as the coexistence of cells with different genetic composition within an
individual, caused by postzygotic somatic mutation. Although somatic mosaicism for …
individual, caused by postzygotic somatic mutation. Although somatic mosaicism for …
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications
A Bonnefond, B Skrobek, S Lobbens, E Eury… - Nature …, 2013 - nature.com
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …
Somatic point mutations occurring early in development: a monozygotic twin study
R Li, A Montpetit, M Rousseau, SYM Wu… - Journal of medical …, 2014 - jmg.bmj.com
The identification of somatic driver mutations in cancer has enabled therapeutic advances
by identifying drug targets critical to disease causation. However, such genomic discoveries …
by identifying drug targets critical to disease causation. However, such genomic discoveries …
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization
of these DNA copy-number changes is important for both the basic understanding of cancer …
of these DNA copy-number changes is important for both the basic understanding of cancer …
Chromosomal alterations among age-related haematopoietic clones in Japan
The extent to which the biology of oncogenesis and ageing are shaped by factors that
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …