The function and regulation of the myometrium, especially during pregnancy, labour and
birth are important in reproductive physiology. It is crucial to understand the mechanisms …

Uterine contractions are important in many reproductive functions including the transport of
sperms and embryo, menstruation, pregnancy and parturition. Improper or irregular uterine …

If we are to develop new strategies for the treatment and management of preterm and
dysfunctional term labour, it is imperative that we improve current understanding of the …

Changes in Ca2+ signals within the myometrium have important functional consequences,
as they determine contractility. We show that the basic phasic nature of uterine contractions …

The regulation of myometrial contraction is of paramount importance for the maintenance of
pregnancy and for parturition. Understanding this regulation involves delineating the …

BACKGROUND Uterine contractile activity plays an important role in many and varied
reproductive functions including sperm and embryo transport, implantation, menstruation …

Understanding the basis for the control of myometrial contractant and relaxant signaling
pathways is important to understanding how to manage myometrial contractions. Signaling …

New Findings What is the topic of this review? To provide an overview of the current
understanding of myometrial contractility and give examples of where this has or is close to …

Myometrial contractility is a complex and dynamic physiological process that changes
substantially during pregnancy and culminates in childbirth. Uterine contractions are …

An increase in the concentration of free calcium in the cytoplasm is essential for the initiation
of contraction in smooth muscle. This calcium may be released from stores within the cell …