Facile synthesis of platelet-activating factor and racemic analogs containing unsaturation in the sn-1-alkyl chain
JR Surles, RL Wykle, JT O'Flaherty… - Journal of medicinal …, 1985 - ACS Publications
Platelet-activating factor, 1 (PAF, l-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine), and
octadecyl-PAF were synthesized chemically as the racemates. The sn-lO-alkyl isomers were …
octadecyl-PAF were synthesized chemically as the racemates. The sn-lO-alkyl isomers were …
Tritiated hexadecyl platelet activating factor (PAF)
SD Wyrick, JS McClanahan, RL Wykle… - Journal of Labelled …, 1985 - Wiley Online Library
We report the synthesis of the natural isomer of [3H]‐lyso platelet activating factor,[3H]‐lyso
PAF (1‐0‐[9′, 10′‐3H2]‐hexadecyl‐2‐lyso‐sn‐glycero‐3‐phosphocholine) and its …
PAF (1‐0‐[9′, 10′‐3H2]‐hexadecyl‐2‐lyso‐sn‐glycero‐3‐phosphocholine) and its …
Development, synthesis, and biological evaluation of (-)-trans-(2S, 5S)-2-[3-[(2-oxopropyl) sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3, 4, 5 …
NN Girotra, T Biftu, MM Ponpipom… - Journal of medicinal …, 1992 - ACS Publications
Platelet-activating factor (PAF), primarily 1-O-hexa-decyl-and l-0-octadecyl-2-0-acetyl-sn-
gIycero-3-phosphocholine, is a potent endogenous lipid mediator found in a variety of cells …
gIycero-3-phosphocholine, is a potent endogenous lipid mediator found in a variety of cells …
Chemical and biochemical aspects of platelet activating factor: A novel class of acetylated ether‐linked choline‐phospholipids
F Snyder - Medicinal research reviews, 1985 - Wiley Online Library
“Platelet activating factor”(PAF) was coined in 1972 by Benveniste and collaborators' as the
name of a substance that was released from basophils after IgE stimulation. Various stimuli …
name of a substance that was released from basophils after IgE stimulation. Various stimuli …
An efficient stereocontrolled route to both enantiomers of platelet activating factor and analogs with long-chain esters at C-2: saturated and unsaturated ether …
PN Guivisdalsky, R Bittman - The Journal of Organic Chemistry, 1989 - ACS Publications
Both enantiomers of various ether/ester glycerophosphocholines (R)-and (S)-l, including
platelet activating factor (PAF, 2), have been synthesized from arenesulfonate derivatives of …
platelet activating factor (PAF, 2), have been synthesized from arenesulfonate derivatives of …
Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone.
R Bittman, NM Witzke, TC Lee, ML Blank… - Journal of Lipid …, 1987 - Elsevier
Two platelet-activating factor (PAF) analogs containing a methyl group at C2 of the glycerol
moiety were synthesized, and some of their biochemical properties were investigated. 1-O …
moiety were synthesized, and some of their biochemical properties were investigated. 1-O …
[HTML][HTML] A novel method for the analysis of platelet-activating factor: direct derivatization of glycerophospholipids.
RK Satsangi, JC Ludwig, ST Weintraub… - Journal of lipid …, 1989 - Elsevier
A novel, facile, and sensitive method for the quantitative and complete structure-proof
analysis of platelet-activating factor (PAF) and other glycerophospholipids is described. 1-O …
analysis of platelet-activating factor (PAF) and other glycerophospholipids is described. 1-O …
New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures
F Heymans, E Michel, MC Borrel, B Wichrowski… - … et Biophysica Acta (BBA …, 1981 - Elsevier
A new method of synthesis of octadecyl platelet-activating factor (PAF; 1-O-octadecyl 2-O-
acetyl sn-glycero-3-phosphorylcholine) is described. Its advantage is to proceed by way of …
acetyl sn-glycero-3-phosphorylcholine) is described. Its advantage is to proceed by way of …
Platelet-activating factor and PAF-like mimetics
RE Whatley, GA Zimmerman, SM Prescott… - Lipid Second …, 1996 - Springer
Abstract Platelet-activating factor (PAF; 1-O-alkyl–2-acetyl-sn-glycero-3-phosphocholine;
Fig. 7-1) is a potent bioactive lipid, with a diverse array of biologic effects in isolated systems …
Fig. 7-1) is a potent bioactive lipid, with a diverse array of biologic effects in isolated systems …
[HTML][HTML] Platelet-activating factor: a phospholipid autacoid with diverse actions
ME Venable, GA Zimmerman, TM McIntyre… - Journal of lipid …, 1993 - Elsevier
Platelet-activating factor (PAF, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent
biological mediator that exerts its effects in a variety of cells and tissues (1-3). This …
biological mediator that exerts its effects in a variety of cells and tissues (1-3). This …