In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …

We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Expression profiling using DNA microarrays holds great promise for a variety of research
applications, including the systematic characterization of genes discovered by sequencing …

Somatic mosaicism refers to the occurrence of two genetically distinct populations of cells
within an individual, derived from a postzygotic mutation. In contrast to inherited mutations …

Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …

Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …

The extent to which the biology of oncogenesis and ageing are shaped by factors that
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Mosaicism is defined as the coexistence of cells with different genetic composition within an
individual, caused by postzygotic somatic mutation. Although somatic mosaicism for …