[HTML][HTML] Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis

L Wang, C Liu, L Wang, B Tang - European journal of pharmacology, 2023 - Elsevier
Cerebral ischaemia-reperfusion injury (CIRI) is a critical component of ischaemic stroke
pathogenesis. Ferroptosis contributes to and aggravates CIRI, whereas the P62/Kelch-like …

[HTML][HTML] Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis

M Li, Z Meng, S Yu, J Li, Y Wang, W Yang… - Chemico-biological …, 2022 - Elsevier
Accumulating evidence have indicated that ferroptosis plays a crucial role in cerebral
ischemia-reperfusion (I/R) injury which is the most serious treatment complication of …

[HTML][HTML] Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway

Z Liu, Z Zhou, P Ai, C Zhang, J Chen… - Frontiers in …, 2022 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a severe type of stroke featuring exceptionally high rate
of morbidity and mortality due to the lack of effective management. Ferroptosis can be …

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway

H Liu, T Zhang, WY Zhang, SR Huang, Y Hu… - Experimental …, 2023 - Elsevier
Background Ischemic stroke, a major cause of death and disability worldwide, results from
reduced blood flow to the brain, leading to irreversible neuronal damage. Recent evidence …

Angong Niuhuang Wan inhibit ferroptosis on ischemic and hemorrhagic stroke by activating PPARγ/AKT/GPX4 pathway

X Bai, E Zheng, L Tong, Y Liu, X Li, H Yang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Angong Niuhuang Wan (AGNHW) is a
prescription from traditional Chinese medicine (TCM) that has been used for centuries to …

[HTML][HTML] Edaravone Ameliorates Cerebral Ischemia–Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats

W Liu, L Wang, C Liu, Z Dai, T Li… - Biological and …, 2022 - jstage.jst.go.jp
Edaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury
(CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate …

Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice

Y Liu, Y Mi, Y Wang, Q Meng, L Xu, Y Liu, D Zhou… - Phytomedicine, 2023 - Elsevier
Background Ischemic stroke (IS) is considered as a serious cerebral vascular disease.
Ferroptosis is a novel type of regulated cell death (RCD), that closely related to the …

Propofol inhibits ferroptotic cell death through the Nrf2/Gpx4 signaling pathway in the mouse model of cerebral ischemia–reperfusion injury

G Fan, Y Li, G Xu, A Zhao, H Jin, S Sun, S Qi - Neurochemical Research, 2023 - Springer
Ferroptosis is characterized by excessive accumulation of iron and lipid peroxides, which
are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an …

Roots of Astragalus propinquus Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia‐Reperfusion Injury

J Chen, D Ma, J Bao, Y Zhang… - … and Alternative Medicine, 2022 - Wiley Online Library
Background. The dried roots of the Astragalus propinquus Schischkin (RAP) plant, as a
traditional Chinese medicine, has been widely used to treat stroke, cerebral ischemia, qi …

[HTML][HTML] Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice

S Yang, L Wang, Y Zeng, Y Wang, T Pei, Z Xie, Q Xiong… - Phytomedicine, 2023 - Elsevier
Background Alzheimer's disease (AD) is a neurogenerative disease and remains no
effective method for stopping its progress. Ferroptosis and adaptive immunity have been …