Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
R Robinson, VA Barathi, SS Chaurasia… - Disease models & …, 2012 - journals.biologists.com
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
one of the major causes of blindness worldwide. The pathogenesis of DR has been …
one of the major causes of blindness worldwide. The pathogenesis of DR has been …
Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model
G Shivashankar, JC Lim… - Journal of Ophthalmology, 2023 - Wiley Online Library
Purpose. Recent evidence has shown that retinal inflammation is a key player in diabetic
retinopathy (DR) pathogenesis. To further understand and validate the metabolic biomarkers …
retinopathy (DR) pathogenesis. To further understand and validate the metabolic biomarkers …
[HTML][HTML] Implications of diabetes-induced altered metabolites on retinal neurodegeneration
Diabetic retinopathy (DR) is one of the major complications of diabetic eye diseases,
causing vision loss and blindness worldwide. The concept of diabetic retinopathy has …
causing vision loss and blindness worldwide. The concept of diabetic retinopathy has …
[HTML][HTML] Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy
H Chen, X Zhang, N Liao, Y Ji, L Mi, Y Gan… - Frontiers in …, 2022 - frontiersin.org
Purpose To investigate the expression of Glucagon-like peptide-1 receptor (GLP-1R),
sodium-glucose co-transporter (SGLT) 1, SGLT2, Glucose transporter type 1 (GLUT1) and …
sodium-glucose co-transporter (SGLT) 1, SGLT2, Glucose transporter type 1 (GLUT1) and …
Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression
Aims Retinopathy is a neurodegenerative complication associating diabetes mellitus.
Diabetic retinopathy (DR) is the primary reason of visual loss during early adulthood. DR …
Diabetic retinopathy (DR) is the primary reason of visual loss during early adulthood. DR …
[HTML][HTML] Cell-cell communication in diabetic retinopathy
S Roy, D Kim, R Lim - Vision research, 2017 - Elsevier
In diabetic retinopathy, high glucose (HG)-mediated breakdown in cell-cell communication
promotes disruption of retinal homeostasis. Several studies indicate that HG condition alters …
promotes disruption of retinal homeostasis. Several studies indicate that HG condition alters …
[HTML][HTML] Manifestation of Pathology in Animal Models of Diabetic Retinopathy Is Delayed from the Onset of Diabetes
S Cubillos, A Kazlauskas - International Journal of Molecular Sciences, 2024 - mdpi.com
Diabetic retinopathy (DR) is the most common complication that develops in patients with
diabetes mellitus (DM) and is the leading cause of blindness worldwide. Fortunately, sight …
diabetes mellitus (DM) and is the leading cause of blindness worldwide. Fortunately, sight …
[HTML][HTML] The role of insulin resistance in experimental diabetic retinopathy—Genetic and molecular aspects
P Järgen, A Dietrich, AW Herling, HP Hammes… - PloS one, 2017 - journals.plos.org
Background Diabetic retinopathy is characterized by defects in the retinal neurovascular
unit. The underlying mechanisms of impairment–including reactive intermediates and …
unit. The underlying mechanisms of impairment–including reactive intermediates and …
Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy
Diabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not
producing enough insulin or when the insulin that it does produce is not able to be used …
producing enough insulin or when the insulin that it does produce is not able to be used …
[HTML][HTML] Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs
RP Kandpal, HK Rajasimha, MJ Brooks… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose To define gene expression changes associated with diabetic retinopathy in a
mouse model using next generation sequencing, and to utilize transcriptome signatures to …
mouse model using next generation sequencing, and to utilize transcriptome signatures to …