Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

R Robinson, VA Barathi, SS Chaurasia… - Disease models & …, 2012 - journals.biologists.com
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
one of the major causes of blindness worldwide. The pathogenesis of DR has been …

Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model

G Shivashankar, JC Lim… - Journal of Ophthalmology, 2023 - Wiley Online Library
Purpose. Recent evidence has shown that retinal inflammation is a key player in diabetic
retinopathy (DR) pathogenesis. To further understand and validate the metabolic biomarkers …

[HTML][HTML] Implications of diabetes-induced altered metabolites on retinal neurodegeneration

DI Aldosari, A Malik, AS Alhomida, MS Ola - Frontiers in neuroscience, 2022 - frontiersin.org
Diabetic retinopathy (DR) is one of the major complications of diabetic eye diseases,
causing vision loss and blindness worldwide. The concept of diabetic retinopathy has …

[HTML][HTML] Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy

H Chen, X Zhang, N Liao, Y Ji, L Mi, Y Gan… - Frontiers in …, 2022 - frontiersin.org
Purpose To investigate the expression of Glucagon-like peptide-1 receptor (GLP-1R),
sodium-glucose co-transporter (SGLT) 1, SGLT2, Glucose transporter type 1 (GLUT1) and …

Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression

HMF Mohammad, MM Sami, S Makary, EA Toraih… - Life sciences, 2019 - Elsevier
Aims Retinopathy is a neurodegenerative complication associating diabetes mellitus.
Diabetic retinopathy (DR) is the primary reason of visual loss during early adulthood. DR …

[HTML][HTML] Cell-cell communication in diabetic retinopathy

S Roy, D Kim, R Lim - Vision research, 2017 - Elsevier
In diabetic retinopathy, high glucose (HG)-mediated breakdown in cell-cell communication
promotes disruption of retinal homeostasis. Several studies indicate that HG condition alters …

[HTML][HTML] Manifestation of Pathology in Animal Models of Diabetic Retinopathy Is Delayed from the Onset of Diabetes

S Cubillos, A Kazlauskas - International Journal of Molecular Sciences, 2024 - mdpi.com
Diabetic retinopathy (DR) is the most common complication that develops in patients with
diabetes mellitus (DM) and is the leading cause of blindness worldwide. Fortunately, sight …

[HTML][HTML] The role of insulin resistance in experimental diabetic retinopathy—Genetic and molecular aspects

P Järgen, A Dietrich, AW Herling, HP Hammes… - PloS one, 2017 - journals.plos.org
Background Diabetic retinopathy is characterized by defects in the retinal neurovascular
unit. The underlying mechanisms of impairment–including reactive intermediates and …

Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy

J Matthews, L Herat, J Rooney, E Rakoczy… - Bioscience …, 2022 - portlandpress.com
Diabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not
producing enough insulin or when the insulin that it does produce is not able to be used …

[HTML][HTML] Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs

RP Kandpal, HK Rajasimha, MJ Brooks… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose To define gene expression changes associated with diabetic retinopathy in a
mouse model using next generation sequencing, and to utilize transcriptome signatures to …