Gene therapy for sensorineural hearing loss
WW Chien, EL Monzack, DS McDougald… - Ear and …, 2015 - journals.lww.com
Gene therapy is a promising treatment modality that is being explored for several inherited
disorders. Multiple human gene therapy clinical trials are currently ongoing, but few are …
disorders. Multiple human gene therapy clinical trials are currently ongoing, but few are …
[HTML][HTML] Innovative optogenetic strategies for vision restoration
CK Baker, JG Flannery - Frontiers in cellular neuroscience, 2018 - frontiersin.org
The advent of optogenetics has ushered in a new era in neuroscience where spatiotemporal
control of neurons is possible through light application. These tools used to study neural …
control of neurons is possible through light application. These tools used to study neural …
[HTML][HTML] Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
For individuals with severe to profound hearing loss resulting from irreversibly damaged hair
cells, cochlear implants can be used to restore hearing by delivering electrical stimulation …
cells, cochlear implants can be used to restore hearing by delivering electrical stimulation …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
[HTML][HTML] Genetic hearing loss and gene therapy
NT Carpena, MY Lee - Genomics & informatics, 2018 - ncbi.nlm.nih.gov
Genetic hearing loss crosses almost all the categories of hearing loss which includes the
following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital …
following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital …
Hearing protection, restoration, and regeneration: an overview of emerging therapeutics for inner ear and central hearing disorders
AGM Schilder, MP Su, H Blackshaw, L Lustig… - Otology & …, 2019 - journals.lww.com
Objective: To provide an overview of biotechnology and pharmaceutical companies active in
the field of inner ear and central hearing disorders and their therapeutic approaches …
the field of inner ear and central hearing disorders and their therapeutic approaches …
Retinal prosthetics, optogenetics, and chemical photoswitches
Three technologies have emerged as therapies to restore light sensing to profoundly blind
patients suffering from late-stage retinal degenerations:(1) retinal prosthetics,(2) …
patients suffering from late-stage retinal degenerations:(1) retinal prosthetics,(2) …
[HTML][HTML] A history of optogenetics: the development of tools for controlling brain circuits with light
ES Boyden - F1000 biology reports, 2011 - ncbi.nlm.nih.gov
Understanding how different kinds of neuron in the brain work together to implement
sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron …
sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron …
Towards translational optogenetics
Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
[HTML][HTML] Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway
Optogenetics provides a means to dissect the organization and function of neural circuits.
Optogenetics also offers the translational promise of restoring sensation, enabling …
Optogenetics also offers the translational promise of restoring sensation, enabling …