[HTML][HTML] Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

L Qiao, S Hu, K Huang, T Su, Z Li, A Vandergriff… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death worldwide and patients are in urgent need of
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …

Genetically engineered cell-derived nanoparticles for targeted breast cancer immunotherapy

X Shi, Q Cheng, T Hou, M Han, G Smbatyan, JE Lang… - Molecular therapy, 2020 - cell.com
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their
unique and pharmacologically important properties, cell-derived exosome nanoparticles …

Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs

W Chen, X Liu, M Lv, L Chen, J Zhao, S Zhong, M Ji… - PloS one, 2014 - journals.plos.org
Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but
their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate …

Exosome-like nanovectors for drug delivery in cancer

N Arrighetti, C Corbo, M Evangelopoulos… - Current medicinal …, 2019 - ingentaconnect.com
Cancer treatment still represents a formidable challenge, despite substantial advancements
in available therapies being made over the past decade. One major issue is poor …

Tumor-targeted exosomes for delivery of anticancer drugs

R Raguraman, D Bhavsar, D Kim, X Ren, V Sikavitsas… - Cancer letters, 2023 - Elsevier
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …

Exosome-based drug delivery: translation from bench to clinic

HB Koh, HJ Kim, SW Kang, TH Yoo - Pharmaceutics, 2023 - mdpi.com
Exosome-based drug delivery is emerging as a promising field with the potential to
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …

Engineered exosomes for targeted transfer of siRNA to HER2 positive breast cancer cells

SK Limoni, MF Moghadam, SM Moazzeni… - Applied biochemistry …, 2019 - Springer
Exosomes are the best options for gene targeting, because of their natural, nontoxic, non-
immunogenic, biodegradable, and targetable properties. By engineering exosome …

Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer

L Zhang, X Yang, Y Lv, X Xin, C Qin, X Han, L Yang… - Scientific reports, 2017 - nature.com
Co-delivery of microRNAs and chemotherapeutic drugs into tumor cells is an attractive
strategy for synergetic breast cancer therapy due to their complementary mechanisms. In …

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

K Jeong, YJ Yu, JY You, WJ Rhee, JA Kim - Lab on a Chip, 2020 - pubs.rsc.org
Non-small cell lung cancer (NSCLC) is one of the leading causes of death from cancer
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …

Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues

SE Emam, ASA Lila, NE Elsadek, H Ando… - European Journal of …, 2019 - Elsevier
Exosomes are gaining increasing attention as drug delivery vehicles due to their low toxicity
and ability to functionally transfer biological cargos between cells. However, the therapeutic …