[HTML][HTML] Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
Cancer is the second leading cause of death worldwide and patients are in urgent need of
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …
Genetically engineered cell-derived nanoparticles for targeted breast cancer immunotherapy
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their
unique and pharmacologically important properties, cell-derived exosome nanoparticles …
unique and pharmacologically important properties, cell-derived exosome nanoparticles …
Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs
W Chen, X Liu, M Lv, L Chen, J Zhao, S Zhong, M Ji… - PloS one, 2014 - journals.plos.org
Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but
their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate …
their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate …
Exosome-like nanovectors for drug delivery in cancer
Cancer treatment still represents a formidable challenge, despite substantial advancements
in available therapies being made over the past decade. One major issue is poor …
in available therapies being made over the past decade. One major issue is poor …
Tumor-targeted exosomes for delivery of anticancer drugs
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …
Exosome-based drug delivery: translation from bench to clinic
HB Koh, HJ Kim, SW Kang, TH Yoo - Pharmaceutics, 2023 - mdpi.com
Exosome-based drug delivery is emerging as a promising field with the potential to
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …
Engineered exosomes for targeted transfer of siRNA to HER2 positive breast cancer cells
Exosomes are the best options for gene targeting, because of their natural, nontoxic, non-
immunogenic, biodegradable, and targetable properties. By engineering exosome …
immunogenic, biodegradable, and targetable properties. By engineering exosome …
Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer
L Zhang, X Yang, Y Lv, X Xin, C Qin, X Han, L Yang… - Scientific reports, 2017 - nature.com
Co-delivery of microRNAs and chemotherapeutic drugs into tumor cells is an attractive
strategy for synergetic breast cancer therapy due to their complementary mechanisms. In …
strategy for synergetic breast cancer therapy due to their complementary mechanisms. In …
Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model
Non-small cell lung cancer (NSCLC) is one of the leading causes of death from cancer
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …
Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues
Exosomes are gaining increasing attention as drug delivery vehicles due to their low toxicity
and ability to functionally transfer biological cargos between cells. However, the therapeutic …
and ability to functionally transfer biological cargos between cells. However, the therapeutic …