Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer

M Kobayashi, K Sawada, M Miyamoto… - Biochemical and …, 2020 - Elsevier
MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS)
miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to …

Exosomes as drug carriers for cancer therapy

JE Pullan, MI Confeld, JK Osborn, J Kim… - Molecular …, 2019 - ACS Publications
Exosomes, biological extracellular vesicles, have recently begun to find use in targeted drug
delivery in solid tumor research. Ranging from 30–120 nm in size, exosomes are secreted …

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

Y Lin, Y Lu, X Li - Journal of Drug Targeting, 2020 - Taylor & Francis
A primary focus of pharmacology is the accurate transport of drugs from the peripheral veins
and their delivery to specific tissues and organs. Exosomes are nanoscale extracellular …

Delivery of engineered primary tumor-derived exosomes effectively suppressed the colorectal cancer chemoresistance and liver metastasis

C Huang, Y Zhou, X Feng, J Wang, Y Li, X Yao - ACS nano, 2023 - ACS Publications
Liver metastasis is one of the major causes of colorectal cancer (CRC)-related morbidity and
mortality. Delivering small interfering RNAs (siRNAs) or noncoding RNAs has been reported …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

[HTML][HTML] The therapeutic potential and clinical significance of exosomes as carriers of drug delivery system

T Li, X Li, G Han, M Liang, Z Yang, C Zhang, S Huang… - Pharmaceutics, 2022 - mdpi.com
Drug delivery system (DDS) realizes the drug delivery process through the drug carrier. As
an important part of DDS, the selection of the drug carrier material is extremely critical, which …

Exosomes as tools to suppress primary brain tumor

M Katakowski, M Chopp - Cellular and molecular neurobiology, 2016 - Springer
Exosomes are small microvesicles released by cells that efficiently transfer their molecular
cargo to other cells, including tumor. Exosomes may pass the blood–brain barrier and have …

Targeted delivery of doxorubicin to HER2 positive tumor models

H Gomari, M Forouzandeh Moghadam… - International journal …, 2019 - Taylor & Francis
Background: Exosomes are natural nanovesicles with unique characteristics, such as long
circulating half-life, the intrinsic ability to target tissues, biocompatibility, and minimal or no …

Exosomes as nano-theranostic delivery platforms for gene therapy

A Tan, J Rajadas, AM Seifalian - Advanced drug delivery reviews, 2013 - Elsevier
Exosomes are biological membrane vesicles measuring 30 to 100nm. They contain an
abundance of small molecules like tetraspanins, receptors for targeting and adhesion, lipids …

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment

A Srivastava, J Filant, KM Moxley, A Sood… - Current gene …, 2015 - ingentaconnect.com
Exosomes are 30-100 nm bodies secreted from almost all types of cells into the extracellular
spaces. They enclose in their lumen active genetic information in the form of messenger …