Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment

A Srivastava, J Filant, KM Moxley, A Sood… - Current gene …, 2015 - ingentaconnect.com
Exosomes are 30-100 nm bodies secreted from almost all types of cells into the extracellular
spaces. They enclose in their lumen active genetic information in the form of messenger …

Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor …

SS Yang, S Ma, H Dou, F Liu, SY Zhang, C Jiang… - Experimental cell …, 2020 - Elsevier
Objective To explore the effects of breast cancer (BC)-derived exosomes on invasion and
migration of BC cells. Methods Exosomes (Exo-MA, Exo-M7, Exo-M1) were extracted from …

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Q Yang, S Li, H Ou, Y Zhang, G Zhu, S Li… - Journal of …, 2024 - Springer
Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …

Post isolation modification of exosomes for nanomedicine applications

JL Hood - Nanomedicine, 2016 - Taylor & Francis
Exosomes are extracellular nanovesicles. They innately possess ideal structural and
biocompatible nanocarrier properties. Exosome components can be engineered at the …

Development and regulation of exosome‐based therapy products

EV Batrakova, MS Kim - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Recently, various innovative therapies involving the ex vivo manipulation and subsequent
reintroduction of exosome‐based therapeutics into humans have been developed and …

Exosomes as nano-theranostic delivery platforms for gene therapy

A Tan, J Rajadas, AM Seifalian - Advanced drug delivery reviews, 2013 - Elsevier
Exosomes are biological membrane vesicles measuring 30 to 100nm. They contain an
abundance of small molecules like tetraspanins, receptors for targeting and adhesion, lipids …

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Z Chen, M Xiong, J Tian, D Song, S Duan… - Journal of …, 2024 - Springer
Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed by a lipid
bilayer membrane containing various biologically active cargoes such as proteins, lipids …

Exosomes as novel bio-carriers for gene and drug delivery

XC Jiang, JQ Gao - International journal of pharmaceutics, 2017 - Elsevier
Clinical treatments have stalled in certain diseases due to a lack of proper therapeutic
delivery systems. Recent studies have identified exosomes for their potential use as cell-free …

Hybrid nanoparticle system integrating tumor-derived exosomes and poly (amidoamine) dendrimers: implications for an effective gene delivery platform

A Nair, K Javius-Jones, J Bugno… - Chemistry of …, 2023 - ACS Publications
Nanoscale drug delivery systems for cancer treatment have demonstrated promising results
in enhancing the selectivity of therapeutic agents while reducing their toxic side effects …

Chemically edited exosomes with dual ligand purified by microfluidic device for active targeted drug delivery to tumor cells

J Wang, W Li, L Zhang, L Ban, P Chen… - … applied materials & …, 2017 - ACS Publications
Exosomes, which are lipid membrane-bound nanovesicles (50–150 nm in diameter), have
aroused extensive attention for their potential applications in invasive molecular and stand …