Characterization of the substrate specificity of α1, 3galactosyltransferase utilizing modified N-acetyllactosamine disaccharides

CLM Stults, BA Macher, R Bhatti, OP Srivastava… - …, 1999 - academic.oup.com
Abstract α1, 3galactosyltransferase (α1, 3GalT) catalyzes the synthesis of a range of
glycoconjugates containing the Galα1, 3Gal epitope which is recognized by the naturally …

Chemical synthesis and kinetic characterization of UDP-2-deoxy-d-lyxo-hexose (“UDP-2-deoxy-d-galactose”), a donor-substrate for β-(1→ 4)-d-galactosyltransferase

G Srivastava, O Hindsgaul, MM Palcic - Carbohydrate research, 1993 - Elsevier
Abstract Bovine β-(1→ 4)-galactosyltransferase (GalT) transfers galactose from UDP-
galactose to β-d-GlcpNAc-terminating oligosaccharides to produce N-acetyllactosamine …

UDP-N-Acetyl-α-D-glucosamine as acceptor substrate of β-1, 4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine

L Elling, A Zervosen, R Gutiérrez Gallego… - Glycoconjugate …, 1999 - Springer
The capacity of UDP-N-acetyl-α-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor
substrate for β-1, 4-galactosyltransferase (β4GalT1, EC 2.4. 1.38) from human and bovine …

α1→ 3‐Galactosyltransferase: the use of recombinant enzyme for the synthesis of α‐galactosylated glycoconjugates

DH Joziasse, NL Shaper, LS Salyer… - European journal of …, 1990 - Wiley Online Library
We have reported the isolation and characterization of a bovine cDNA clone containing the
complete coding sequence for UDP‐Gal: Galβ1→ 4GlcNAc α→ 3‐galactosyltransferase …

Highly efficient chemoenzymatic synthesis of α-galactosyl epitopes with a recombinant α (1→ 3)-galactosyltransferase

J Fang, J Li, X Chen, Y Zhang, J Wang… - Journal of the …, 1998 - ACS Publications
α-Galactosyl epitopes are carbohydrate structures bearing a Galα1-3Galβ terminus. The
interaction of these epitopes on the surface of animal cells with anti-α-galactosyl antibodies …

Alpha-Galactosyl trisaccharide epitope: Modification of the 6-primary positions and recognition by human anti-αGal antibody

PR Andreana, P Kowal, AJ Janczuk, PG Wang - Glycoconjugate journal, 2003 - Springer
Abstract Galactose oxidase (EC 1.1. 3.9, GAO) was used to convert the C-6′ OH of Galβ
(1→ 4) Glcβ–OBn (5) to the corresponding hydrated aldehyde (7). Chemical modification …

Synthesis of Hexp-(1→ 4)-β-d-GlcpNac-(1→ 2)-α-d-Manp-(1→ O)(CH2) 7CH3 probes for exploration of the substrate specificity of glycosyltransferases: Part II, Hex= 3 …

JALM van Dorst, CJ van Heusden, JM Tikkanen… - Carbohydrate …, 1997 - Elsevier
Seven analogues of the trisaccharide β-d-Galp-(1→ 4)-β-d-GlcpNAc-(1→ 2)-α-d-Manp-(1→
O)(CH2) 7CH3 have been synthesized as potential substrates for glycosyltransferases …

Generation of α1, 3galactosyltransferase deficient mice

AD Thall - α-Gal and Anti-Gal: α1, 3-Galactosyltransferase, α-Gal …, 1999 - Springer
All mammals, with the exception of apes, Old World monkeys, and humans possess a
functional α1, 3GT gene (Galili et al., 1990). Microsomal preparations from tissues of …

Investigations on β1, 4-galactosyltransferase I using 6-sulfo-GlcNAc as an acceptor sugar substrate

B Ramakrishnan, AJ Moncrief, TA Davis… - Glycoconjugate …, 2013 - Springer
sulfate modified N-acetylglucosamine (6-sulfo-GlcNAc) is often found as part of many
biologically important carbohydrate epitopes such as 6-sulfo-Le X. In these epitopes, the 6 …

UDP-6-deoxy-6-fluoro-α-d-galactose binds to two different galactosyltransferases, but neither can effectively catalyze transfer of the modified galactose to the …

CL Schengrund, P Kováč - Carbohydrate research, 1999 - Elsevier
The effect of substitution of the HO-6 of d-galactose with fluorine on the ability of α-(1→ 3)-
galactosyltransferase (EC 2.4. 1.151) and β-(1→ 4)-galactosyltransferase (EC 2.4. 1.22) to …