Tuberculosis (TB) is caused by the intracellular bacteria Mycobacterium tuberculosis, and
kills more than 1.5 million people every year worldwide. Immunity to TB is associated with …

Background Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while …

The complex molecular events that occur within the host during the establishment of a
Mycobacterium tuberculosis infection are poorly defined, thus preventing identification of …

In this study, we report a new approach that allows dissection of distinct pathways regulating
induction of early adaptive immunity in response to Mycobacterium tuberculosis (Mtb). We …

We report the enrichment of and immune responses mediated by genes expressed by
Mycobacterium tuberculosis inside macrophages as a function of time. Results indicate that …

Tuberculosis (TB) poses a great challenge to immunologists, as it represents a chronic
infection characterized by persistence of the pathogen despite development of antigen …

Infection with Mycobacterium tuberculosis causes the illness tuberculosis with an annual
mortality of≈ 2 million. Understanding the nature of the host-pathogen interactions at …

Early immune responses to Mycobacterium tuberculosis (Mtb) invasion of the human lung
play a decisive role in the outcome of infection, leading to either rapid clearance of the …

Alveolar macrophages (AMs) are major targets of Mycobacterium tuberculosis (Mtb)
infection, critical during the progression of active tuberculosis (TB). The complex …

Background Tuberculosis (TB), a bacterial infection caused by Mycobacterium tuberculosis
(Mtb) remains a significant health problem worldwide with a third of the world population …