Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …

Abstract Hypericum (St John's Wort) is a plant that has been used for centuries as a
medicinal herb. Pre-clinical animals studies suggest that hypericum is effective in three …

Highlights•This is the most up-to-date, large-scale meta-analysis of St John's wort.•Studies
published in English, German and Chinese were examined.•27 clinical trials with a total of …

Depression is one of the most common reasons for using complementary and alternative
therapies. The aim of this article is to provide an overview of the evidence available on the …

Preparations from St. John's wort extracts are used in the treatment of depression in many
countries and represent an accepted alternative to synthetic antidepressants or behavioural …

The use of complementary and alternative medicine (CAM) has increased among patients
with psychiatric disorders, as it has in the general population, over recent decades …

Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit
diverse pharmacological activities. In recent years, screening has revealed a wide variety of …

Objectives Depressive disorders are persistent, recurring illnesses that impose enormous
personal suffering on individuals and their families. Major depression alone is estimated as …

Abstract Studies concluding that St. John's wort (Hypericum perforatum) is an effective
antidepressant can be challenged due to questionable methodology. We attempt to correct …

The efficacy of antidepressant medication is generally thought to be well established,
whereas that of hypericum (St John's wort) is considered doubtful. The data fail to support …